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Translational Medicine / 转化医学TIM-3 Biology, T Cell Exhaustion Checkpoint

Alexander Anderson

PhD

🏢Brigham and Women's Hospital / Harvard Medical School🌐USA

Principal Investigator, Cancer Immunology Program

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👥Biography 个人简介

Alexander Anderson is a leading basic scientist in the TIM-3 checkpoint pathway, having characterized the biology of TIM-3 as an inhibitory molecule on exhausted CD8+ T cells and a regulator of innate immune cell function. His fundamental work on the structure, ligands, and signaling of TIM-3 formed the scientific basis for the clinical development of anti-TIM-3 antibodies including sabatolimab. He has investigated TIM-3 in the context of tumor immunity and hematologic malignancies, and his publications are foundational references for the checkpoint inhibitor field.

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🧪Research Fields 研究领域

TIM-3 T cell exhaustion biology
anti-TIM-3 clinical development sabatolimab
checkpoint molecule TIM-3 galectin-9
T cell exhaustion reinvigoration
TIM-3 hematologic malignancies

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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