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Translational Medicine / 转化医学PROTAC Design, Structural Biology

Alessio Ciulli

PhD

🏢University of Dundee🌐UK

Professor of Chemical Structural Biology

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👥Biography 个人简介

Professor Alessio Ciulli is a world-leading expert in PROTAC design and structural biology of targeted protein degradation. His laboratory has solved crystal structures of PROTAC ternary complexes and used these to guide the rational design of highly selective degraders of cancer-relevant proteins including BRD4 and other bromodomain-containing proteins. His structural insights have become foundational to the PROTAC drug discovery field.

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🧪Research Fields 研究领域

PROTAC targeted protein degradation design
VHL E3 ligase structural biology
ternary complex PROTAC structural basis
BET bromodomain PROTAC
structure-based PROTAC optimization

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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