Alessandro D. Santin
亚历山德罗·桑廷
MD
Professor of Obstetrics, Gynecology and Reproductive Sciences; Director, GYN Oncology Research妇产科及生殖科学教授；妇科肿瘤研究主任
👥Biography 个人简介
Alessandro D. Santin, MD is a professor at Yale Cancer Center and a world leader in HER2-targeted therapy for uterine serous carcinoma. He established trastuzumab and pertuzumab as active agents in HER2-overexpressing endometrial cancer through seminal clinical and translational studies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Trastuzumab in HER2-Overexpressing Uterine Serous Carcinoma
Conducted the first prospective trials demonstrating trastuzumab significantly improves PFS in HER2/neu-overexpressing uterine serous carcinoma, establishing a new standard for this aggressive subtype.
Dual HER2 Blockade with Pertuzumab and Trastuzumab
Led early-phase trials combining pertuzumab and trastuzumab in HER2+ uterine serous carcinoma, demonstrating additive antitumor activity and informing ongoing phase III studies.
Representative Works 代表性著作
Trastuzumab as initial therapy in advanced or recurrent HER2/neu-overexpressing uterine serous carcinoma
Journal of Clinical Oncology (2018)
Randomized phase II trial establishing trastuzumab benefit in HER2+ uterine serous carcinoma with significantly prolonged PFS as first-line therapy.
Pertuzumab and trastuzumab in HER2-positive advanced uterine serous carcinoma
Gynecologic Oncology (2021)
Demonstrated dual HER2 blockade with pertuzumab and trastuzumab as a promising strategy in HER2-overexpressing uterine serous carcinoma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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