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Translational Medicine / 转化医学Pancreatic Cancer Metabolism, KRAS Biology

Alec Kimmelman

MD, PhD

🏢NYU Langone Health🌐USA

Chair, Department of Radiation Oncology

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👥Biography 个人简介

Dr. Alec Kimmelman is a pioneering researcher who has revealed how pancreatic cancer cells exploit autophagy and metabolic reprogramming driven by KRAS oncogene activation to survive in a nutrient-poor tumor microenvironment. His work has identified novel metabolic vulnerabilities in PDAC, including the role of autophagy and macropinocytosis in fueling pancreatic tumor cell growth, opening new therapeutic avenues.

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🧪Research Fields 研究领域

PDAC autophagy
KRAS-driven metabolism
pancreatic cancer mitochondria
PDAC stromal interactions
metabolic vulnerabilities PDAC

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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