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Translational Medicine / 转化医学Immune Checkpoints, Antibody Mechanisms

Alan Korman

PhD

🏢Bristol Myers Squibb🌐USA

Vice President, Immuno-Oncology Discovery

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👥Biography 个人简介

Dr. Alan Korman is a pioneer in checkpoint antibody development who led anti-CTLA-4 ipilimumab research at BMS, helping translate Jim Allison's discovery into clinical therapy. He has contributed to understanding how the Fc region and isotype of checkpoint antibodies influence mechanism of action, including Treg depletion in tumors versus systemic toxicity. His continued work on engineering next-generation checkpoint antibodies with optimized Fc effector functions informs the pipeline of novel immuno-oncology therapeutics.

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🧪Research Fields 研究领域

anti-CTLA-4 antibody mechanism
checkpoint antibody Fc engineering
ipilimumab mechanism of action
Treg depletion checkpoint antibodies
next generation checkpoint antibody design

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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