Alan L. Ho
何亮
MD, PhD
Associate Attending Physician; Associate Professor of Medicine, Weill Cornell Medical College副主治医师；威尔康奈尔医学院医学副教授
👥Biography 个人简介
Dr. Alan Ho at MSK is a physician-scientist specializing in thyroid and endocrine cancers, with pioneering contributions to BRAF V600E-targeted therapy (dabrafenib+trametinib) and RET-inhibitor trials. His translational research bridges molecular biology and clinical outcomes in rare thyroid cancers.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BRAF V600E-Targeted Combination Therapy
Led the pivotal phase II basket trial establishing dabrafenib plus trametinib for BRAF V600E-mutated anaplastic thyroid carcinoma, achieving ~69% overall response rate and securing accelerated FDA approval in 2018.
RET Inhibitor Development
Conducted early-phase clinical trials of selective RET inhibitors (selpercatinib, pralsetinib) in RET-altered thyroid cancers, establishing new treatment options for medullary and papillary thyroid cancer patients.
Representative Works 代表性著作
Combination dabrafenib and trametinib in patients with BRAF V600E-mutated anaplastic thyroid carcinoma
Journal of Clinical Oncology (2020)
Updated analysis of the pivotal basket trial confirming durable responses with BRAF/MEK inhibition in anaplastic thyroid cancer, supporting standard-of-care adoption.
Selpercatinib in patients with RET-mutant medullary thyroid cancer
NEJM (2020)
Phase I/II LIBRETTO-001 trial demonstrating high response rates of selpercatinib in RET-mutant medullary thyroid cancer, leading to FDA approval.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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