Gregory Adams

Gregory Adams has made fundamental contributions to understanding the pharmacokinetics and tumor penetration of antibody therapeutics including bispecific antibodies at Fox Chase Cancer Center. His mathematical modeling of the binding site barrier effect demonstrated how antibody affinity, size, and valency influence tumor penetration, insights that are critical for optimizing bifunctional antibody design for solid tumor applications. His work informs the rational design of bispecific antibodies with balanced binding properties for optimal tumor targeting and immune cell engagement.