Thomas Tuschl

Thomas Tuschl is a pioneer in RNA interference who demonstrated that synthetic siRNAs could silence genes in mammalian cells. This discovery opened the door to RNAi therapeutics, leading to FDA-approved siRNA drugs for genetic diseases. His work has profound implications for cancer treatment through targeted gene silencing.

Thomas Tuschl是RNA干扰的先驱，他证明了合成siRNA可以在哺乳动物细胞中沉默基因。这一发现为RNAi治疗打开了大门，产生了用于遗传疾病的FDA批准的siRNA药物。他的工作通过靶向基因沉默对癌症治疗具有深远影响。