Federico Mingozzi
Ph.D.
Chief Scientific Officer
👥Biography 个人简介
Federico Mingozzi is an expert in AAV immunology and has made fundamental contributions to understanding immune responses to gene therapy vectors. His research has been instrumental in developing strategies to overcome pre-existing immunity to AAV and managing immune responses in clinical trials. Mingozzi's work has been particularly impactful for liver-directed gene therapy in hemophilia, contributing to the development of approved gene therapies.
Federico Mingozzi是AAV免疫学专家,在理解基因治疗载体免疫反应方面做出了基础性贡献。他的研究在开发克服AAV预存免疫力和管理临床试验免疫反应策略方面发挥了重要作用。Mingozzi的工作对血友病肝脏定向基因治疗产生了特别重要的影响,促进了已获批基因治疗药物的开发。
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
AAV Immunology
Characterized T cell responses to AAV capsid antigens in clinical trials, leading to immunomodulation strategies.
Hemophilia Gene Therapy
Key contributions to preclinical and clinical development of liver-directed factor VIII and IX gene therapy.
Representative Works 代表性著作
CD8+ T-cell responses to adeno-associated virus capsid in humans
Nature Medicine (2007)
First demonstration that T cell responses to AAV capsid can limit gene therapy efficacy in humans.
Immune responses to AAV in clinical trials
Current Gene Therapy (2011)
Comprehensive review of immune challenges in AAV gene therapy clinical development.
📄Data Sources 数据来源
Last updated: 2026-03-04 | All information from publicly available academic sources
Related Experts 相关专家
关注 Federico Mingozzi 的研究动态
Follow Federico Mingozzi's research updates
留下邮箱,当我们发布与 Federico Mingozzi(Spark Therapeutics / University of Paris)相关的新研究或访谈时,我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment