Paul H. Sugarbaker
保罗·舒加贝克
MD, FACS, FRCS
Director, Center for Gastrointestinal Malignancies胃肠道恶性肿瘤中心主任
👥Biography 个人简介
Paul H. Sugarbaker, MD is Director of the Center for Gastrointestinal Malignancies at the Washington Cancer Institute and is universally recognized as the founder of the combined cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) treatment strategy for peritoneal surface malignancies. Over more than four decades, he developed, refined, and globally disseminated this approach, transforming peritoneal carcinomatosis from a uniformly fatal condition to one where long-term survival — and in selected cases cure — became achievable. Dr. Sugarbaker developed the peritonectomy procedures and the Peritoneal Cancer Index (PCI), now the universally adopted staging and patient selection tool for CRS-HIPEC. His prospective studies in appendiceal neoplasms, particularly pseudomyxoma peritonei, demonstrated 10- and 20-year survival rates that fundamentally changed the nihilistic view of peritoneal dissemination. His subsequent work extended CRS-HIPEC to colorectal, gastric, and mesothelioma peritoneal metastases, supported by phase III trial evidence. Dr. Sugarbaker founded the Peritoneal Surface Oncology Group International (PSOGI), organized international training programs, and edited the definitive textbooks in the field. He has trained over 200 surgeons from more than 40 countries and his protocols are used in major CRS-HIPEC centers on every continent. He is among the most cited surgical oncologists in history, with landmark publications spanning the Annals of Surgery, Journal of Clinical Oncology, and the New England Journal of Medicine.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Development of CRS-HIPEC for Peritoneal Carcinomatosis
Pioneered the combined cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) approach, developing standardized peritonectomy procedures and the Peritoneal Cancer Index (PCI) scoring system, creating the foundation for curative-intent treatment of appendiceal, colorectal, and gastric peritoneal metastases.
Long-Term Outcomes in Pseudomyxoma Peritonei
Reported the first large series demonstrating 10-year overall survival rates exceeding 70% in pseudomyxoma peritonei treated with complete CRS-HIPEC, conclusively establishing this approach as the standard of care and overturning prior management with systemic chemotherapy alone.
Peritoneal Cancer Index and Patient Selection
Developed and validated the Peritoneal Cancer Index (PCI), a 13-region scoring tool (0–39) that quantifies disease burden at CRS and predicts complete cytoreduction likelihood and survival, adopted universally as the standard staging and selection tool in peritoneal oncology.
Representative Works 代表性著作
The Peritoneal Cancer Index: A Critical Review
Surgical Oncology Clinics of North America (2022)
Comprehensive review of PCI methodology, validation data, and optimal cutoff values across tumor histologies, summarizing 30 years of evidence supporting PCI as the primary selection tool for CRS-HIPEC.
Long-Term Survival After Cytoreductive Surgery and HIPEC for Colorectal Peritoneal Metastases: Updated Results from the Washington Cancer Institute
Annals of Surgical Oncology (2023)
Updated single-institution outcomes of 400+ colorectal peritoneal metastasis patients demonstrating median OS of 41 months and 5-year OS of 32% after complete cytoreduction, with PCI and completeness of cytoreduction as dominant prognostic factors.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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