Paul Nghiem
保罗·义
MD, PhD
Professor and Head, Division of Dermatology; Endowed Chair in Skin Oncology Research皮肤科主任教授；皮肤肿瘤学研究讲席教授
👥Biography 个人简介
Paul Nghiem is the world's foremost expert on Merkel cell carcinoma (MCC), a rare and aggressive skin cancer. He led the pivotal trial of avelumab establishing the first FDA-approved therapy for MCC, identified the Merkel cell polyomavirus, and directs a comprehensive MCC clinical and research program at University of Washington.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Merkel Cell Carcinoma Immunotherapy
Led the pivotal JAVELIN Merkel 200 trial of avelumab, resulting in the first FDA approval of any therapy for metastatic Merkel cell carcinoma and transforming survival outcomes.
Merkel Cell Polyomavirus Research
Collaborated in characterizing the role of Merkel cell polyomavirus in MCC pathogenesis, providing biological rationale for the immunogenicity and immunotherapy sensitivity of MCC.
MCC Disease Registry and Natural History
Established a global MCC patient registry and natural history database, enabling population-level insights, prognostic markers, and streamlined clinical trial accrual.
Representative Works 代表性著作
PD-L1 Blockade with Avelumab for Metastatic Merkel Cell Carcinoma (JAVELIN Merkel 200)
Lancet Oncology (2016)
Pivotal study demonstrating durable responses with avelumab in chemotherapy-refractory MCC, leading to the first FDA approval for this aggressive skin cancer.
Programmed Death-1 Blockade with Pembrolizumab in Merkel Cell Carcinoma
Journal of Clinical Oncology (2016)
Established anti-PD-1 therapy as highly effective first-line treatment for MCC, with high response rates and prolonged durable remissions.
Merkel Cell Polyomavirus Is Commonly Present in and Transcriptionally Active in Merkel Cell Carcinomas
Journal of Investigative Dermatology (2009)
Confirmed widespread presence and transcriptional activity of MCPyV in MCC tumors, establishing the virus as central to MCC biology.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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