J. Keith Joung
M.D., Ph.D.
Professor, Pathology
👥Biography 个人简介
Keith Joung is an expert in genome editing who has developed methods to improve CRISPR specificity and reduce off-target effects. His work on high-fidelity Cas9 variants and guide RNA engineering has been essential for therapeutic applications where precision is critical. Joung co-founded Editas Medicine.
Keith Joung是基因组编辑专家,开发了提高CRISPR特异性和减少脱靶效应的方法。他在高保真Cas9变体和引导RNA工程方面的工作对于需要精确性的治疗应用至关重要。Joung联合创立了Editas Medicine。
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
High-Fidelity CRISPR
Developed high-specificity Cas9 variants (eSpCas9, SpCas9-HF1).
Off-Target Detection
Created GUIDE-seq method for unbiased off-target detection.
Representative Works 代表性著作
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Nature (2016)
High-fidelity Cas9 variants for therapeutic use.
📄Data Sources 数据来源
Last updated: 2026-03-05 | All information from publicly available academic sources
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