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Gene Therapy / 基因治疗Gene Editing

J. Keith Joung

M.D., Ph.D.

🏢Massachusetts General Hospital🌐USA

Professor, Pathology

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Key Papers
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Key Contributions

👥Biography 个人简介

Keith Joung is an expert in genome editing who has developed methods to improve CRISPR specificity and reduce off-target effects. His work on high-fidelity Cas9 variants and guide RNA engineering has been essential for therapeutic applications where precision is critical. Joung co-founded Editas Medicine.

Keith Joung是基因组编辑专家,开发了提高CRISPR特异性和减少脱靶效应的方法。他在高保真Cas9变体和引导RNA工程方面的工作对于需要精确性的治疗应用至关重要。Joung联合创立了Editas Medicine。

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🧪Research Fields 研究领域

Gene Editing基因编辑
CRISPR SpecificityCRISPR特异性
Genome Engineering基因组工程

🎓Key Contributions 主要贡献

High-Fidelity CRISPR

Developed high-specificity Cas9 variants (eSpCas9, SpCas9-HF1).

Off-Target Detection

Created GUIDE-seq method for unbiased off-target detection.

Representative Works 代表性著作

[1]

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects

Nature (2016)

High-fidelity Cas9 variants for therapeutic use.

📄Data Sources 数据来源

Last updated: 2026-03-05 | All information from publicly available academic sources

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