John L. Rinn

John Rinn is a pioneer in the discovery and functional characterization of long non-coding RNAs (lncRNAs). His work has revealed that lncRNAs play critical roles in gene regulation, development, and disease, including cancer. Rinn's discovery of HOTAIR, a lncRNA that regulates chromatin state, provided a paradigm for understanding how non-coding transcripts control gene expression.

John Rinn是长链非编码RNA（lncRNA）发现和功能表征的先驱。他的工作揭示了lncRNA在基因调控、发育和疾病（包括癌症）中发挥的关键作用。Rinn对HOTAIR（一种调节染色质状态的lncRNA）的发现为理解非编码转录本如何控制基因表达提供了范式。