Harriet Kluger
哈丽特·克卢格
MD
Professor of Medicine (Medical Oncology); Co-Director, Yale SPORE in Skin Cancer内科学教授（肿瘤内科）；耶鲁皮肤癌SPORE项目联合主任
👥Biography 个人简介
Harriet Kluger is a leading melanoma specialist at Yale Cancer Center, recognized for her expertise in uveal melanoma, melanoma brain metastases, and novel therapeutics. She co-directs Yale's NCI-funded SPORE in Skin Cancer and has advanced immunotherapy and targeted therapy for these challenging disease presentations.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Uveal Melanoma Therapeutics
Led clinical trials of novel agents including tebentafusp in uveal melanoma, demonstrating first survival benefit in this rare and chemotherapy-refractory disease.
Melanoma Brain Metastases
Conducted clinical research on checkpoint inhibitors and targeted therapies for melanoma brain metastases, an area historically excluded from major trials, improving outcomes for this poor-prognosis population.
Predictive Biomarkers
Investigated tissue and blood-based biomarkers of immunotherapy response and resistance in melanoma, including tumor mutational burden and immune cell infiltration patterns.
Representative Works 代表性著作
Tebentafusp in Metastatic Uveal Melanoma (IMCgp100-202)
New England Journal of Medicine (2021)
Landmark trial demonstrating first-ever overall survival benefit in metastatic uveal melanoma with tebentafusp, establishing a new treatment standard for this rare cancer.
Ipilimumab plus Nivolumab in Melanoma Brain Metastases
Journal of Clinical Oncology (2021)
Demonstrated efficacy of dual checkpoint blockade in active melanoma brain metastases, providing evidence supporting systemic immunotherapy in CNS disease.
Combined BRAF and MEK Inhibition in Melanoma Brain Metastases
Lancet Oncology (2017)
Showed combined dabrafenib/trametinib intracranial activity in BRAF-mutant melanoma brain metastases, supporting targeted therapy use in CNS disease.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Keith Flaherty
Massachusetts General Hospital / Harvard Medical School
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