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Gene Therapy / 基因治疗Gene Editing

Gerald Schwank

Ph.D.

🏢ETH Zurich🌐Switzerland

Professor, Institute of Pharmacology

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Key Papers
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Key Contributions

👥Biography 个人简介

Gerald Schwank is a pioneer in applying CRISPR-Cas9 to correct genetic diseases. His work demonstrated functional correction of cystic fibrosis in patient-derived organoids, providing proof-of-concept for CRISPR gene therapy. Schwank continues to advance in vivo gene editing approaches for genetic diseases.

Gerald Schwank是应用CRISPR-Cas9矫正遗传疾病的先驱。他的工作证明了在患者来源的类器官中功能性矫正囊性纤维化,为CRISPR基因治疗提供了概念验证。Schwank继续推进遗传疾病的体内基因编辑方法。

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🧪Research Fields 研究领域

Gene Correction基因矫正
CRISPR TherapeuticsCRISPR治疗
Organoids类器官

🎓Key Contributions 主要贡献

Organoid Gene Correction

First demonstration of CRISPR gene correction in patient organoids.

Liver Gene Editing

Advancing in vivo CRISPR approaches for liver diseases.

Representative Works 代表性著作

[1]

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

Cell Stem Cell (2013)

First CRISPR correction in patient organoids.

📄Data Sources 数据来源

Last updated: 2026-03-05 | All information from publicly available academic sources

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