Carlo M. Croce
M.D.
Director, Human Cancer Genetics Program
👥Biography 个人简介
Carlo Croce is a pioneer in cancer genetics who discovered the critical role of microRNAs in cancer development. His laboratory demonstrated that specific microRNAs function as oncogenes or tumor suppressors, and that microRNA dysregulation is a universal feature of human cancers. Croce's work has opened new avenues for cancer diagnosis and therapy based on non-coding RNA biology.
Carlo Croce是癌症遗传学的先驱,发现了microRNA在癌症发展中的关键作用。他的实验室证明特定的microRNA作为癌基因或肿瘤抑制因子发挥作用,并且microRNA失调是人类癌症的普遍特征。Croce的工作为基于非编码RNA生物学的癌症诊断和治疗开辟了新途径。
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
miRNA Cancer Biology
First to demonstrate microRNA involvement in human cancer (CLL).
miRNA Signatures
Developed microRNA expression signatures for cancer classification and prognosis.
Representative Works 代表性著作
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
Proceedings of the National Academy of Sciences (2002)
First demonstration that microRNA genes are involved in human cancer.
A microRNA expression signature of human solid tumors defines cancer gene targets
Proceedings of the National Academy of Sciences (2006)
Pan-cancer microRNA signatures for tumor classification.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-03-04 | All information from publicly available academic sources
Related Experts 相关专家
James M. Wilson
University of Pennsylvania
Guangping Gao
University of Massachusetts Chan Medical School
Federico Mingozzi
Spark Therapeutics / University of Paris
Feng Zhang
Broad Institute / MIT
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