Zhen Fan
范臻
MD, PhD
Professor, Department of Experimental Therapeutics实验治疗学系教授
👥Biography 个人简介
Dr. Zhen Fan is a leading molecular oncologist at MD Anderson known for foundational work on EGFR signaling in pancreatic and other cancers. His laboratory has elucidated intrinsic and acquired resistance mechanisms to EGFR-targeted therapies, informing rational combination strategies to overcome treatment failure.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
EGFR Signaling in PDAC
Characterized EGFR pathway activation in pancreatic cancer, defined crosstalk with downstream KRAS and PI3K effectors, and identified molecular determinants of sensitivity versus resistance to anti-EGFR agents.
Overcoming Targeted Therapy Resistance
Elucidated multiple mechanisms of intrinsic and acquired resistance to receptor-targeted therapies in PDAC, providing mechanistic rationale for combination regimens currently in clinical evaluation.
Representative Works 代表性著作
Cetuximab-Induced Receptor Dimerization Mediates Constitutive Src and STAT3 Activation in EGFR-Expressing Cancer Cells
Cancer Biology and Therapy (2010)
Revealed a paradoxical resistance mechanism to cetuximab involving constitutive STAT3 activation via receptor dimerization.
Dual Inhibition of EGFR and c-Met Kinase Overcomes Resistance to Cetuximab in KRAS Wild-Type Colorectal and Pancreatic Cancer
Molecular Cancer Therapeutics (2012)
Demonstrated that c-Met co-targeting abrogates EGFR-inhibitor resistance, supporting dual-receptor combination strategies in PDAC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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