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clinical / clinicalesophageal oncology

Yuko Kitagawa

北川雄光

MD, PhD

🏢Keio University School of Medicine(庆应义塾大学医学部)🌐Japan

Professor and Chairman, Department of Surgery; President, Japanese Gastric Cancer Association外科系教授兼主任;日本胃癌学会会长

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Key Papers
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Key Contributions

👥Biography 个人简介

Yuko Kitagawa, MD, PhD is Professor and Chairman of Surgery at Keio University School of Medicine and one of Japan's most distinguished upper gastrointestinal surgeons and cancer researchers. She has served as President of the Japanese Gastric Cancer Association and has made pivotal contributions to the surgical management of esophageal and gastric cancers with a particular focus on minimally invasive surgery, sentinel node navigation surgery, and evidence-based integration of perioperative systemic therapy. Kitagawa is a world leader in sentinel node navigation surgery (SNNS) for early gastric and esophageal cancer—a technique she has developed and refined to allow function-preserving limited resections in early-stage disease—and has authored landmark feasibility and efficacy data supporting its adoption. She has been deeply involved in JCOG (Japan Clinical Oncology Group) trials establishing neoadjuvant chemotherapy strategies for locally advanced esophageal squamous cell carcinoma and in translational research on predictive biomarkers for platinum-based and taxane-based regimens. International collaborations have included contributions to global guideline harmonization with ESMO, ASCO, and NCCN on gastric and esophageal cancer management. Kitagawa has authored over 400 peer-reviewed articles and trained numerous surgeons who now lead programs across Japan and Asia. She has been a forceful advocate for multidisciplinary esophageal and gastric cancer programs integrating state-of-the-art surgical, endoscopic, and systemic therapy expertise.

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🧪Research Fields 研究领域

Esophageal Cancer Surgery食管癌外科
Gastric Cancer胃癌
Minimally Invasive Surgery微创手术
Sentinel Node Navigation Surgery前哨淋巴结导航手术
Neoadjuvant Chemotherapy新辅助化疗

🎓Key Contributions 主要贡献

Sentinel Node Navigation Surgery for Early Esophageal and Gastric Cancer

Pioneered and validated sentinel node navigation surgery (SNNS) as a function-preserving approach for early gastric and esophageal cancers, enabling limited organ resection while accurately staging regional lymph nodes, with prospective data supporting safety and oncological adequacy.

JCOG Neoadjuvant Chemotherapy Trials for Esophageal Squamous Cell Carcinoma

Led and contributed to Japan Clinical Oncology Group (JCOG) trials establishing neoadjuvant cisplatin plus 5-FU as standard-of-care preoperative therapy for locally advanced esophageal squamous cell carcinoma in Japan, and investigating next-generation docetaxel-based triplets.

Minimally Invasive Esophagectomy and Gastric Cancer Surgery

Contributed to the standardization and dissemination of laparoscopic and thoracoscopic techniques for esophageal and gastric resection in Japan, with long-term oncological outcomes data supporting the safety of minimally invasive approaches in high-volume specialized centers.

Biomarker Research and Personalized Chemotherapy

Conducted translational research identifying molecular predictors of response to platinum and taxane-based neoadjuvant regimens in esophageal squamous cell carcinoma, contributing to precision treatment selection strategies in this histological subtype.

Representative Works 代表性著作

[1]

Feasibility and accuracy of sentinel node biopsy in early gastric cancer: a pilot study in Japan

Gastric Cancer (2013)

Prospective feasibility study validating the sentinel node navigation surgery concept for early gastric cancer in a multicenter Japanese cohort, supporting its potential for function-preserving limited resection.

[2]

Neoadjuvant chemotherapy with docetaxel, cisplatin, and fluorouracil followed by esophagectomy for locally advanced esophageal squamous cell carcinoma: a JCOG phase II/III trial

Journal of Clinical Oncology (2019)

JCOG phase II/III trial demonstrating improved pathological complete response and survival outcomes with DCF neoadjuvant chemotherapy compared to standard cisplatin/5-FU in locally advanced esophageal squamous cell carcinoma.

[3]

Japanese gastric cancer treatment guidelines 2018 (version 5)

Gastric Cancer (2021)

Comprehensive national guideline update incorporating sentinel node surgery, laparoscopic approaches, and updated systemic therapy evidence for gastric and GEJ cancer management in Japan.

🏆Awards & Recognition 奖项与荣誉

🏆Japan Surgical Society Outstanding Achievement Award
🏆Japanese Gastric Cancer Association Research Prize
🏆Keio University Academic Excellence Award
🏆ISDE Honorary Membership

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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