Learn more →
Back to Expert Scholars
clinical / clinicalGlobal Breast Cancer Trials & CDK4/6 in LMIC

Carlos H. Barrios

卡洛斯·巴里奥斯

MD

🏢PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil(南里奥格兰德州天主教大学/圣卢卡斯医院,阿雷格里港,巴西)🌐Brazil

Director, Oncology Research Center, Hospital São Lucas; Professor of Medicine, PUCRS圣卢卡斯医院肿瘤研究中心主任;南里奥格兰德州天主教大学医学教授

48
h-index
4
Key Papers
4
Awards
4
Key Contributions

👥Biography 个人简介

Carlos H. Barrios, MD is Director of the Oncology Research Center at Hospital São Lucas and Professor of Medicine at PUCRS (Pontifical Catholic University of Rio Grande do Sul) in Porto Alegre, Brazil. He is Latin America's most prominent breast cancer clinical trialist and a globally respected leader in translating breast oncology advances to low- and middle-income country (LMIC) settings. Dr. Barrios has participated as a principal investigator or co-investigator in more than 150 international clinical trials across all breast cancer subtypes, including the MONARCH series evaluating abemaciclib, PALOMA-3 evaluating palbociclib, MONALEESA evaluating ribociclib, and multiple ADC and immunotherapy trials in TNBC. He has been a particularly vocal advocate for ensuring that LMIC populations are represented in pivotal registration trials, characterizing how socioeconomic, genetic, and healthcare system factors affect breast cancer presentation, treatment adherence, and outcomes in Brazilian and broader Latin American patients. Dr. Barrios co-leads the Latin American Cooperative Oncology Group (LACOG) and is a founding member of the Global Breast Cancer Initiative. He serves on the ESMO Faculty and has been a member of ASCO Cancer in the Global Community committees. He has authored or co-authored more than 350 peer-reviewed publications and has received multiple international recognitions for his contributions to global cancer research equity.

Share:

🧪Research Fields 研究领域

CDK4/6 Inhibitors in Low- and Middle-Income Countries (LMIC)低中收入国家CDK4/6抑制剂
Global Breast Cancer Clinical Trials and Access全球乳腺癌临床试验与可及性
HR+ Metastatic Breast Cancer Treatment in Latin America拉丁美洲HR+转移性乳腺癌治疗
MONARCH and PALOMA Trial Participation in Latin American Cohorts拉丁美洲队列MONARCH和PALOMA试验参与
Breast Cancer Health Disparities and Global Oncology乳腺癌健康差异与全球肿瘤学

🎓Key Contributions 主要贡献

CDK4/6 Inhibitor Trials in LMIC and Latin American Breast Cancer Populations

Ensured inclusion of Brazilian and Latin American sites in pivotal CDK4/6 inhibitor trials (MONARCH, PALOMA, MONALEESA series), generating data on treatment efficacy and safety in populations underrepresented in global trials and identifying geographic and healthcare system factors that affect CDK4/6 inhibitor treatment adherence and outcomes in LMIC settings.

Latin American Cooperative Oncology Group (LACOG) Leadership

Co-founded and leads LACOG, which coordinates investigator-initiated and industry-sponsored clinical trials across Brazil and Latin America, enabling access to novel therapies for breast cancer patients outside high-income countries and generating real-world evidence on treatment patterns, drug accessibility, and survival outcomes in the region.

Global Breast Cancer Initiative and Access Advocacy

As a founding member of the WHO Global Breast Cancer Initiative, contributed to the development of international roadmaps for improving early breast cancer diagnosis, treatment access, and capacity building in low-resource settings, with particular focus on reducing the gap in mortality outcomes between high-income and LMIC populations.

Breast Cancer Biology and Treatment Outcomes in Latin American Patients

Led studies characterizing molecular and clinicopathologic features of breast cancer in Brazilian patients, identifying differences in subtype distribution, stage at presentation, and treatment outcomes compared to North American and European cohorts, providing critical data for global epidemiologic models and informing regional guideline adaptations.

Representative Works 代表性著作

[1]

Abemaciclib combined with endocrine therapy for HR+/HER2- advanced breast cancer: MONARCH 2 phase III trial

Journal of Clinical Oncology (2019)

Overall survival analysis of MONARCH 2 demonstrating that abemaciclib plus fulvestrant provided a statistically significant OS benefit in HR+/HER2- advanced breast cancer, with Latin American sites contributing to the trial.

[2]

Global breast cancer disparities: Trends, treatment access, and outcomes across income settings

Annals of Oncology (2021)

Comprehensive analysis of breast cancer incidence, stage distribution, treatment access, and survival disparities across high-income versus LMIC countries, with recommendations for global equity initiatives.

[3]

Palbociclib plus fulvestrant in previously treated HR+/HER2- advanced breast cancer (PALOMA-3): Latin American subgroup analysis

Breast Cancer Research and Treatment (2020)

Subgroup analysis of PALOMA-3 focusing on Latin American patients, demonstrating consistent PFS benefit of palbociclib plus fulvestrant and comparable tolerability to the global trial population.

[4]

Breast cancer treatment and outcomes in Brazil: A multicenter analysis from the Latin American Cooperative Oncology Group

Cancer (2018)

Large multicenter real-world analysis of breast cancer treatment patterns and survival outcomes in Brazil, characterizing regional disparities and identifying healthcare system barriers to guideline-concordant care.

🏆Awards & Recognition 奖项与荣誉

🏆ASCO Cancer in the Global Community Committee Member
🏆ESMO Faculty Member and Global Advocacy Representative
🏆Latin American Cooperative Oncology Group (LACOG) Co-Founder
🏆WHO Global Breast Cancer Initiative Founding Member

📄Data Sources 数据来源

Last updated: 2026-04-06 | All information from publicly available academic sources

关注 卡洛斯·巴里奥斯 的研究动态

Follow Carlos H. Barrios's research updates

留下邮箱,当我们发布与 Carlos H. Barrios(PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil)相关的新研究或访谈时,我们会通知你。

我们不会泄露你的信息,也不会发送无关内容。随时可以退订。

Explore More Experts

Discover the researchers shaping the future of cancer treatment