Carlos H. Barrios
卡洛斯·巴里奥斯
MD
Director, Oncology Research Center, Hospital São Lucas; Professor of Medicine, PUCRS圣卢卡斯医院肿瘤研究中心主任;南里奥格兰德州天主教大学医学教授
👥Biography 个人简介
Carlos H. Barrios, MD is Director of the Oncology Research Center at Hospital São Lucas and Professor of Medicine at PUCRS (Pontifical Catholic University of Rio Grande do Sul) in Porto Alegre, Brazil. He is Latin America's most prominent breast cancer clinical trialist and a globally respected leader in translating breast oncology advances to low- and middle-income country (LMIC) settings. Dr. Barrios has participated as a principal investigator or co-investigator in more than 150 international clinical trials across all breast cancer subtypes, including the MONARCH series evaluating abemaciclib, PALOMA-3 evaluating palbociclib, MONALEESA evaluating ribociclib, and multiple ADC and immunotherapy trials in TNBC. He has been a particularly vocal advocate for ensuring that LMIC populations are represented in pivotal registration trials, characterizing how socioeconomic, genetic, and healthcare system factors affect breast cancer presentation, treatment adherence, and outcomes in Brazilian and broader Latin American patients. Dr. Barrios co-leads the Latin American Cooperative Oncology Group (LACOG) and is a founding member of the Global Breast Cancer Initiative. He serves on the ESMO Faculty and has been a member of ASCO Cancer in the Global Community committees. He has authored or co-authored more than 350 peer-reviewed publications and has received multiple international recognitions for his contributions to global cancer research equity.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CDK4/6 Inhibitor Trials in LMIC and Latin American Breast Cancer Populations
Ensured inclusion of Brazilian and Latin American sites in pivotal CDK4/6 inhibitor trials (MONARCH, PALOMA, MONALEESA series), generating data on treatment efficacy and safety in populations underrepresented in global trials and identifying geographic and healthcare system factors that affect CDK4/6 inhibitor treatment adherence and outcomes in LMIC settings.
Latin American Cooperative Oncology Group (LACOG) Leadership
Co-founded and leads LACOG, which coordinates investigator-initiated and industry-sponsored clinical trials across Brazil and Latin America, enabling access to novel therapies for breast cancer patients outside high-income countries and generating real-world evidence on treatment patterns, drug accessibility, and survival outcomes in the region.
Global Breast Cancer Initiative and Access Advocacy
As a founding member of the WHO Global Breast Cancer Initiative, contributed to the development of international roadmaps for improving early breast cancer diagnosis, treatment access, and capacity building in low-resource settings, with particular focus on reducing the gap in mortality outcomes between high-income and LMIC populations.
Breast Cancer Biology and Treatment Outcomes in Latin American Patients
Led studies characterizing molecular and clinicopathologic features of breast cancer in Brazilian patients, identifying differences in subtype distribution, stage at presentation, and treatment outcomes compared to North American and European cohorts, providing critical data for global epidemiologic models and informing regional guideline adaptations.
Representative Works 代表性著作
Abemaciclib combined with endocrine therapy for HR+/HER2- advanced breast cancer: MONARCH 2 phase III trial
Journal of Clinical Oncology (2019)
Overall survival analysis of MONARCH 2 demonstrating that abemaciclib plus fulvestrant provided a statistically significant OS benefit in HR+/HER2- advanced breast cancer, with Latin American sites contributing to the trial.
Global breast cancer disparities: Trends, treatment access, and outcomes across income settings
Annals of Oncology (2021)
Comprehensive analysis of breast cancer incidence, stage distribution, treatment access, and survival disparities across high-income versus LMIC countries, with recommendations for global equity initiatives.
Palbociclib plus fulvestrant in previously treated HR+/HER2- advanced breast cancer (PALOMA-3): Latin American subgroup analysis
Breast Cancer Research and Treatment (2020)
Subgroup analysis of PALOMA-3 focusing on Latin American patients, demonstrating consistent PFS benefit of palbociclib plus fulvestrant and comparable tolerability to the global trial population.
Breast cancer treatment and outcomes in Brazil: A multicenter analysis from the Latin American Cooperative Oncology Group
Cancer (2018)
Large multicenter real-world analysis of breast cancer treatment patterns and survival outcomes in Brazil, characterizing regional disparities and identifying healthcare system barriers to guideline-concordant care.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-04-06 | All information from publicly available academic sources
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