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clinical / clinicalsoft tissue sarcoma clinical trials

Sant Chawla

桑特·奇瓦拉

MD

🏢Sarcoma Oncology Research Center, Santa Monica(圣莫尼卡肉瘤肿瘤研究中心)🌐USA

Director主任

52
h-index
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Key Papers
2
Awards
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Key Contributions

👥Biography 个人简介

Sant Chawla is a leading sarcoma oncologist who has contributed to pivotal trials of systemic therapies in soft tissue sarcoma. He led clinical investigations of trabectedin, eribulin, and multiple cytotoxic and targeted agents in dedifferentiated liposarcoma, leiomyosarcoma, and other STS histotypes. Chawla is a key participant in NCI sarcoma working groups and has generated significant evidence on MDM2 amplification as a diagnostic and potentially therapeutic target in well-differentiated/dedifferentiated liposarcoma. His research spans first-in-human trials to multi-site phase III studies across rare histotype-specific populations.

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🧪Research Fields 研究领域

soft tissue sarcoma软组织肉瘤
MDM2 amplificationMDM2扩增
eribulin sarcoma艾日布林肉瘤
trabectedin曲贝替定
leiomyosarcoma平滑肌肉瘤

🎓Key Contributions 主要贡献

Eribulin in Liposarcoma

Led clinical investigation of eribulin in soft tissue sarcoma including its phase III evaluation in liposarcoma, contributing to FDA approval for this indication and establishing a new standard treatment option.

MDM2 Liposarcoma Biology

Characterized MDM2 gene amplification as a defining feature of well-differentiated and dedifferentiated liposarcoma, advancing its use as a diagnostic biomarker and supporting development of MDM2 inhibitors for this indication.

Representative Works 代表性著作

[1]

Trabectedin in Soft-Tissue and Bone Sarcomas: A Phase II Study

Journal of Clinical Oncology (2009)

Phase II evidence for trabectedin in soft tissue sarcoma.

[2]

Eribulin Mesylate versus Dacarbazine in Previously Treated Patients with Advanced Liposarcoma or Leiomyosarcoma

Lancet (2016)

Phase III eribulin superiority in liposarcoma.

🏆Awards & Recognition 奖项与荣誉

🏆Connective Tissue Oncology Society Research Award
🏆ASCO Merit Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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