Sant Chawla
桑特·奇瓦拉
MD
Director主任
👥Biography 个人简介
Sant Chawla is a leading sarcoma oncologist who has contributed to pivotal trials of systemic therapies in soft tissue sarcoma. He led clinical investigations of trabectedin, eribulin, and multiple cytotoxic and targeted agents in dedifferentiated liposarcoma, leiomyosarcoma, and other STS histotypes. Chawla is a key participant in NCI sarcoma working groups and has generated significant evidence on MDM2 amplification as a diagnostic and potentially therapeutic target in well-differentiated/dedifferentiated liposarcoma. His research spans first-in-human trials to multi-site phase III studies across rare histotype-specific populations.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Eribulin in Liposarcoma
Led clinical investigation of eribulin in soft tissue sarcoma including its phase III evaluation in liposarcoma, contributing to FDA approval for this indication and establishing a new standard treatment option.
MDM2 Liposarcoma Biology
Characterized MDM2 gene amplification as a defining feature of well-differentiated and dedifferentiated liposarcoma, advancing its use as a diagnostic biomarker and supporting development of MDM2 inhibitors for this indication.
Representative Works 代表性著作
Trabectedin in Soft-Tissue and Bone Sarcomas: A Phase II Study
Journal of Clinical Oncology (2009)
Phase II evidence for trabectedin in soft tissue sarcoma.
Eribulin Mesylate versus Dacarbazine in Previously Treated Patients with Advanced Liposarcoma or Leiomyosarcoma
Lancet (2016)
Phase III eribulin superiority in liposarcoma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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