Ursula A. Matulonis
乌尔苏拉·马图洛尼斯
MD
Chief, Division of Gynecologic Oncology妇科肿瘤学部主任
👥Biography 个人简介
Ursula Matulonis is a leading gynecologic oncologist who has led transformative clinical trials in ovarian cancer, particularly in the platinum-resistant setting where treatment options remain limited. She was a principal investigator of the SORAYA and MIRASOL trials establishing mirvetuximab soravtansine as the first ADC approved for platinum-resistant ovarian cancer with high FRalpha expression. Matulonis has led studies of PARP inhibitors in BRCA-mutated ovarian cancer and has driven development of novel immune and antibody-based approaches for this difficult-to-treat malignancy. She co-chairs multiple NCI cooperative group trials in gynecologic oncology.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Mirvetuximab Soravtansine Development
Led pivotal SORAYA and MIRASOL trials establishing mirvetuximab soravtansine as the first ADC for FRalpha-high platinum-resistant ovarian cancer, providing a new treatment option for this previously difficult-to-treat population.
PARP Inhibitor Clinical Development
Contributed foundational clinical trial leadership to olaparib and niraparib development in BRCA-mutated ovarian cancer, contributing to multiple approvals that transformed maintenance therapy standards.
Representative Works 代表性著作
Mirvetuximab Soravtansine in FRalpha-Positive, Platinum-Resistant Ovarian Cancer
New England Journal of Medicine (2023)
MIRASOL trial establishing mirvetuximab soravtansine superiority over chemotherapy in platinum-resistant ovarian cancer.
Activity of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib Against Ovarian Cancer
Journal of Clinical Oncology (2011)
Early clinical validation of PARP inhibitor activity in BRCA-mutated ovarian cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
关注 乌尔苏拉·马图洛尼斯 的研究动态
Follow Ursula A. Matulonis's research updates
留下邮箱,当我们发布与 Ursula A. Matulonis(Dana-Farber Cancer Institute)相关的新研究或访谈时,我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment