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clinical / clinicalovarian cancer medical oncology

Ursula A. Matulonis

乌尔苏拉·马图洛尼斯

MD

🏢Dana-Farber Cancer Institute(丹娜-法伯癌症研究所)🌐USA

Chief, Division of Gynecologic Oncology妇科肿瘤学部主任

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h-index
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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Ursula Matulonis is a leading gynecologic oncologist who has led transformative clinical trials in ovarian cancer, particularly in the platinum-resistant setting where treatment options remain limited. She was a principal investigator of the SORAYA and MIRASOL trials establishing mirvetuximab soravtansine as the first ADC approved for platinum-resistant ovarian cancer with high FRalpha expression. Matulonis has led studies of PARP inhibitors in BRCA-mutated ovarian cancer and has driven development of novel immune and antibody-based approaches for this difficult-to-treat malignancy. She co-chairs multiple NCI cooperative group trials in gynecologic oncology.

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🧪Research Fields 研究领域

ovarian cancer卵巢癌
PARP inhibitorsPARP抑制剂
antibody drug conjugates抗体药物偶联物
mirvetuximab soravtansinemirvetuximab soravtansine
FRalpha targetingFRα靶向治疗

🎓Key Contributions 主要贡献

Mirvetuximab Soravtansine Development

Led pivotal SORAYA and MIRASOL trials establishing mirvetuximab soravtansine as the first ADC for FRalpha-high platinum-resistant ovarian cancer, providing a new treatment option for this previously difficult-to-treat population.

PARP Inhibitor Clinical Development

Contributed foundational clinical trial leadership to olaparib and niraparib development in BRCA-mutated ovarian cancer, contributing to multiple approvals that transformed maintenance therapy standards.

Representative Works 代表性著作

[1]

Mirvetuximab Soravtansine in FRalpha-Positive, Platinum-Resistant Ovarian Cancer

New England Journal of Medicine (2023)

MIRASOL trial establishing mirvetuximab soravtansine superiority over chemotherapy in platinum-resistant ovarian cancer.

[2]

Activity of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib Against Ovarian Cancer

Journal of Clinical Oncology (2011)

Early clinical validation of PARP inhibitor activity in BRCA-mutated ovarian cancer.

🏆Awards & Recognition 奖项与荣誉

🏆SGO Distinguished Service Award
🏆ASCO Merit Award
🏆Dana-Farber Cancer Institute Clinical Excellence Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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