Todd Golub
托德·戈卢布
MD
Chief Scientific Officer, Broad Institute; Director, Cancer Program布罗德研究所首席科学官；癌症项目主任
👥Biography 个人简介
Todd Golub pioneered the use of genomics and machine learning to discover cancer vulnerabilities and match drugs to tumor subtypes. He led foundational gene expression profiling studies that redefined cancer classification and drug response prediction.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Gene Expression-Based Cancer Classification
Demonstrated that DNA microarray gene expression profiles could classify leukemia subtypes with high accuracy, establishing the genomic basis for molecular cancer taxonomy.
Connectivity Map for Drug Discovery
Co-developed the Connectivity Map (CMap), linking gene expression signatures of diseases to drug perturbations, enabling systematic genomics-driven drug repurposing and discovery.
Representative Works 代表性著作
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
Science (1999)
Landmark study showing unsupervised gene expression profiling can discover and predict cancer subtypes, foundational for precision oncology.
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
Science (2006)
Introduced CMap, a resource enabling systematic identification of drugs that reverse disease gene signatures, widely used in drug discovery.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Sebastian Bauer
University Hospital Essen (Universitätsklinikum Essen)
Suzanne George
Dana-Farber Cancer Institute / Harvard Medical School
Marcia S. Brose
Sidney Kimmel Cancer Center, Thomas Jefferson University
Lori J. Wirth
Massachusetts General Hospital, Harvard Medical School
关注 托德·戈卢布 的研究动态
Follow Todd Golub's research updates
留下邮箱，当我们发布与 Todd Golub（Broad Institute / Dana-Farber Cancer Institute）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment