Timothy Cloughesy
蒂莫西·克劳西
MD
Professor and Director, Neuro-Oncology Program神经肿瘤项目主任、教授
👥Biography 个人简介
Timothy Cloughesy is a leading neuro-oncologist at UCLA specializing in GBM immunotherapy and IDH-mutant glioma. He has led landmark clinical trials combining checkpoint inhibitors with standard GBM therapy and is a pioneer in precision oncology approaches for brain tumors.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
GBM Immunotherapy
Led pivotal trials of neoadjuvant PD-1 blockade in GBM, demonstrating immune activation and survival benefits in recurrent glioblastoma patients.
IDH-Mutant Glioma
Advanced understanding of IDH mutation as a therapeutic target and prognostic biomarker, informing treatment stratification in diffuse gliomas.
Clinical Trial Leadership
Directed multiple phase II/III trials through the Pacific Neuro-Oncology Consortium, accelerating novel agent evaluation in brain tumors.
Representative Works 代表性著作
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
Nature Medicine (2019)
Demonstrated neoadjuvant pembrolizumab improved OS in recurrent GBM with measurable immune infiltration changes.
Phase II trial of bevacizumab and temozolomide in recurrent glioblastoma
Journal of Clinical Oncology (2008)
Established bevacizumab plus temozolomide as a viable salvage regimen for recurrent GBM.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Patrick Y. Wen
Dana-Farber Cancer Institute / Harvard Medical School
Michael Weller
University Hospital Zurich / University of Zurich
Susan M. Chang
University of California San Francisco (UCSF)
Roger Stupp
Northwestern University Feinberg School of Medicine
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