Roger Stupp
罗杰·斯图普
MD
Professor of Neurology and Neurological Surgery神经内科及神经外科教授
👥Biography 个人简介
Roger Stupp established the standard-of-care Stupp protocol for GBM (temozolomide + radiotherapy) and led the EF-14 trial demonstrating survival benefit of Tumor Treating Fields. His landmark trials have defined modern GBM management and extended patient survival.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Stupp Protocol
Established concurrent temozolomide plus radiotherapy followed by adjuvant temozolomide as the global standard of care for newly diagnosed GBM.
Tumor Treating Fields (TTFields)
Led the EF-14 phase III trial demonstrating TTFields added to temozolomide maintenance significantly improves OS in newly diagnosed GBM.
MGMT-Guided Therapy
Demonstrated MGMT promoter methylation predicts benefit from temozolomide chemotherapy, enabling personalized GBM treatment.
Representative Works 代表性著作
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
New England Journal of Medicine (2005)
Established the Stupp protocol as GBM standard of care, improving 2-year survival from 10% to 26%.
Effect of Tumor-Treating Fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma (EF-14 trial)
JAMA (2017)
EF-14 trial showed TTFields plus temozolomide improved OS by 4.9 months vs temozolomide alone in GBM.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Health / David Geffen School of Medicine
Patrick Y. Wen
Dana-Farber Cancer Institute / Harvard Medical School
Michael Weller
University Hospital Zurich / University of Zurich
Susan M. Chang
University of California San Francisco (UCSF)
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