Thomas F. Gajewski
M.D., Ph.D.
Professor of Pathology and Medicine
👥Biography 个人简介
Thomas Gajewski is a leader in understanding the tumor microenvironment and innate immune mechanisms that regulate anti-tumor immunity. His research has revealed the STING pathway's role in spontaneous anti-tumor T cell responses and developed strategies to convert non-T cell-inflamed tumors to inflamed phenotypes. Gajewski's work informs rational combination immunotherapy approaches.
Thomas Gajewski是理解肿瘤微环境和调节抗肿瘤免疫的先天免疫机制的领导者。他的研究揭示了STING通路在自发性抗肿瘤T细胞反应中的作用,并开发了将非T细胞浸润肿瘤转化为浸润表型的策略。Gajewski的工作为合理的联合免疫治疗方法提供了信息。
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
STING Pathway
Identified STING as critical for spontaneous anti-tumor T cell priming.
T Cell-Inflamed Phenotype
Characterized molecular determinants of T cell-inflamed versus non-inflamed tumors.
Representative Works 代表性著作
STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon responses
Immunity (2014)
STING pathway in anti-tumor immunity.
📄Data Sources 数据来源
Last updated: 2026-03-04 | All information from publicly available academic sources
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