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clinical / clinicalesophageal and GEJ cancer clinical trials

Ian Chau

周彦

MBBS, MD

🏢Royal Marsden Hospital and Institute of Cancer Research(皇家马斯登医院及癌症研究所)🌐UK

Consultant Medical Oncologist肿瘤科顾问医师

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h-index
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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Ian Chau is a UK GI oncologist who has led or contributed to pivotal trials across esophageal and gastric cancer. He was a UK investigator for FLOT4-AIO and CROSS, contributing European evidence on perioperative chemotherapy and neoadjuvant chemoradiation. Chau contributed to development of trastuzumab deruxtecan in HER2-positive gastric cancer through DESTINY-Gastric trials, demonstrating the ADC activity after trastuzumab progression. He chairs the ESMO GI cancer advisory committee and contributes to upper GI cancer guideline panels. Chau is also active in translational research on molecular biomarkers in upper GI cancer.

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🧪Research Fields 研究领域

esophageal cancer clinical trials食管癌临床试验
FLOT UK英国FLOT
CROSS chemoradiationCROSS同步放化疗
T-DXd gastric cancerT-DXd胃癌
DESTINY-GastricDESTINY-Gastric

🎓Key Contributions 主要贡献

DESTINY-Gastric ADC Development

Contributed to DESTINY-Gastric trials establishing T-DXd as an active regimen in HER2-positive gastric cancer after trastuzumab progression, extending ADC therapy into gastric cancer beyond HER2-low concepts.

UK Upper GI Cancer Clinical Network

Built Royal Marsden upper GI cancer program into a leading UK and European clinical trial site contributing evidence across multiple pivotal gastric and esophageal cancer trials.

Representative Works 代表性著作

[1]

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer (DESTINY-Gastric01)

New England Journal of Medicine (2021)

T-DXd activity in HER2-positive gastric cancer after trastuzumab.

[2]

ESMO Clinical Practice Guidelines: Gastric Cancer

Annals of Oncology (2022)

European gastric cancer treatment guidelines.

🏆Awards & Recognition 奖项与荣誉

🏆ESMO Award for Service to GI Oncology
🏆Royal Marsden Clinician of the Year Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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