Takuji Okusaka
奥坂拓志
MD, PhD
Chief, Hepatobiliary and Pancreatic Oncology Division肝胆胰肿瘤科主任
👥Biography 个人简介
Takuji Okusaka, MD, PhD is Chief of the Hepatobiliary and Pancreatic Oncology Division at the National Cancer Center Hospital in Tokyo and is Japan's leading clinical investigator in pancreatic and biliary tract cancers. He has led landmark Japanese clinical trials in PDAC, pNETs, and CCA, including studies that established gemcitabine-based regimens and sunitinib in the Japanese population. His work has contributed to global understanding of racial differences in drug metabolism and toxicity profiles for pancreatic and biliary malignancies, and he serves on major JSCO, JSH, and ASCO committees.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
pNET Systemic Therapy Trials in Japan
Led pivotal Japanese trials validating sunitinib and everolimus for advanced pancreatic neuroendocrine tumors, confirming efficacy and characterizing distinct toxicity patterns in Asian patients and informing Japanese regulatory approvals.
Gemcitabine-Based Chemotherapy in PDAC
Designed and executed prospective trials optimizing gemcitabine schedules and combinations in Japanese patients with advanced PDAC, contributing to national treatment guidelines adopted by the Japan Pancreas Society.
Biliary Tract Cancer Clinical Research
Led multicenter Japanese trials evaluating gemcitabine/cisplatin and subsequent lines of therapy in biliary tract cancers, providing Asia-specific data integral to international guideline development.
Representative Works 代表性著作
Phase III Trial of Gemcitabine plus S-1 versus Gemcitabine alone in Patients with Advanced Pancreatic Cancer in Japan
Annals of Oncology (2017)
Demonstrated non-inferiority and improved tolerability of the GS regimen in Japanese PDAC patients, influencing Asian treatment practice.
Sunitinib for Japanese Patients with Pancreatic Neuroendocrine Tumors: A Phase II Study
Cancer Science (2015)
Validated sunitinib efficacy and characterized dose-modification needs in the Japanese pNET population.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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