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clinical / clinicalgastric and esophageal cancer targeted therapy

Zev A. Wainberg

泽夫·温伯格

MD

🏢UCLA Jonsson Comprehensive Cancer Center(加州大学洛杉矶分校琼森综合癌症中心)🌐USA

Associate Director for Research, GI Oncology胃肠肿瘤研究副主任

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Zev Wainberg is a GI oncologist who has contributed to development of novel targeted therapies in gastric and gastroesophageal junction cancer including CLDN18.2 targeting. He led investigator participation in the SPOTLIGHT and GLOW trials establishing zolbetuximab plus chemotherapy as first-line therapy for CLDN18.2-positive, HER2-negative gastric cancer, representing a new targetable biomarker beyond HER2 in gastric cancer. Wainberg has contributed to development of FGFR2b inhibitors, fibroblast growth factor receptor targeted agents, and immunotherapy combinations in esophagogastric cancers, and leads a translational research program on gastric cancer biology.

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🧪Research Fields 研究领域

gastric cancer胃癌
HER2 gastric cancerHER2胃癌
CLDN18.2 targetingCLDN18.2靶向治疗
zolbetuximabzolbetuximab
gastroesophageal junction cancer胃食管交界癌

🎓Key Contributions 主要贡献

CLDN18.2 Targeted Therapy

Contributed to clinical development of zolbetuximab (CLDN18.2 antibody) through SPOTLIGHT/GLOW trials demonstrating survival benefit in CLDN18.2-positive gastric cancer, expanding the targetable biomarker landscape beyond HER2.

FGFR2b Inhibitor Development

Contributed to early clinical development of bemarituzumab (FGFR2b antibody) in FGFR2b-overexpressing gastric cancer, providing proof of concept for FGFR2b as a targetable biomarker in upper GI cancers.

Representative Works 代表性著作

[1]

Zolbetuximab plus CAPOX in CLDN18.2-Positive Gastric Cancer (GLOW)

Journal of Clinical Oncology (2024)

GLOW trial establishing zolbetuximab in CLDN18.2-positive gastric cancer.

[2]

Bemarituzumab in Patients with FGFR2b-Selected Gastric or Gastro-Oesophageal Junction Adenocarcinoma (FIGHT)

Lancet Oncology (2021)

Phase II FGFR2b targeting in gastric cancer.

🏆Awards & Recognition 奖项与荣誉

🏆ASCO GI Cancer Research Award
🏆UCLA Cancer Research Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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