Zev A. Wainberg
泽夫·温伯格
MD
Associate Director for Research, GI Oncology胃肠肿瘤研究副主任
👥Biography 个人简介
Zev Wainberg is a GI oncologist who has contributed to development of novel targeted therapies in gastric and gastroesophageal junction cancer including CLDN18.2 targeting. He led investigator participation in the SPOTLIGHT and GLOW trials establishing zolbetuximab plus chemotherapy as first-line therapy for CLDN18.2-positive, HER2-negative gastric cancer, representing a new targetable biomarker beyond HER2 in gastric cancer. Wainberg has contributed to development of FGFR2b inhibitors, fibroblast growth factor receptor targeted agents, and immunotherapy combinations in esophagogastric cancers, and leads a translational research program on gastric cancer biology.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CLDN18.2 Targeted Therapy
Contributed to clinical development of zolbetuximab (CLDN18.2 antibody) through SPOTLIGHT/GLOW trials demonstrating survival benefit in CLDN18.2-positive gastric cancer, expanding the targetable biomarker landscape beyond HER2.
FGFR2b Inhibitor Development
Contributed to early clinical development of bemarituzumab (FGFR2b antibody) in FGFR2b-overexpressing gastric cancer, providing proof of concept for FGFR2b as a targetable biomarker in upper GI cancers.
Representative Works 代表性著作
Zolbetuximab plus CAPOX in CLDN18.2-Positive Gastric Cancer (GLOW)
Journal of Clinical Oncology (2024)
GLOW trial establishing zolbetuximab in CLDN18.2-positive gastric cancer.
Bemarituzumab in Patients with FGFR2b-Selected Gastric or Gastro-Oesophageal Junction Adenocarcinoma (FIGHT)
Lancet Oncology (2021)
Phase II FGFR2b targeting in gastric cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
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Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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