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clinical / clinicallung cancer immunotherapy

Solange Peters

索朗热·彼得斯

MD, PhD

🏢Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne University Hospital(洛桑大学医院)🌐France

Head of Medical Oncology Department肿瘤内科主任

82
h-index
3
Key Papers
4
Awards
3
Key Contributions

👥Biography 个人简介

Solange Peters, MD, PhD, is Head of Medical Oncology at the Lausanne University Hospital (CHUV) in Switzerland and a past President of the European Society for Medical Oncology (ESMO). She is one of Europe's foremost authorities on lung cancer immunotherapy and has made seminal contributions to the development and clinical validation of tumor mutational burden (TMB) as a predictive biomarker for checkpoint inhibitor benefit in NSCLC. Peters led key investigations within the IMpower program evaluating atezolizumab combinations in NSCLC, including the IMpower110 trial that demonstrated superior OS with atezolizumab monotherapy over chemotherapy in PD-L1 high (TC3 or IC3) first-line metastatic NSCLC. As ESMO President she championed guideline harmonization across lung cancer immunotherapy indications and facilitated international consensus on biomarker-driven treatment selection. Peters is deeply engaged in translational research on mechanisms of primary and acquired immunotherapy resistance, particularly the role of STK11/KEAP1 co-mutations in KRAS-mutant NSCLC in blunting PD-L1 pathway responses. She has served on the ESMO Clinical Practice Guidelines committee for lung cancer and chairs multiple international steering committees for ongoing phase III immunotherapy trials. Her dual commitment to clinical excellence and scientific rigor has made her one of the defining voices in European thoracic oncology.

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🧪Research Fields 研究领域

NSCLC非小细胞肺癌
Immunotherapy免疫治疗
Tumor Mutational Burden肿瘤突变负荷
Atezolizumab阿替利珠单抗
IMpower110IMpower110

🎓Key Contributions 主要贡献

Atezolizumab and IMpower Program in NSCLC

Led European investigator participation in IMpower110, establishing atezolizumab as a first-line monotherapy option for metastatic NSCLC with high PD-L1 expression (TC3 or IC3), and contributed to the broader IMpower program evaluating atezolizumab combinations across NSCLC subtypes.

Tumor Mutational Burden as NSCLC Biomarker

Championed prospective evaluation of TMB as a predictive biomarker for immunotherapy benefit in NSCLC, including efforts to standardize TMB assay methodology across platforms and harmonize TMB thresholds for clinical decision-making through ESMO guideline processes.

STK11/KEAP1 Resistance Mechanisms

Investigated co-occurring STK11 and KEAP1 mutations as primary resistance mechanisms to immune checkpoint inhibitors in KRAS-mutant NSCLC, demonstrating that these co-mutations substantially reduce objective response rates and survival benefit despite high PD-L1 expression.

Representative Works 代表性著作

[1]

Atezolizumab versus Docetaxel in Patients with Previously Treated NSCLC (OAK)

The Lancet (2017)

Phase III trial demonstrating superior OS with atezolizumab over docetaxel as second-line therapy for previously treated NSCLC regardless of PD-L1 or KRAS status, contributing to the regulatory approval of atezolizumab in this setting.

[2]

Atezolizumab for First-Line Treatment of PD-L1–Selected Patients with NSCLC (IMpower110)

New England Journal of Medicine (2020)

Phase III trial showing improved OS with atezolizumab monotherapy versus chemotherapy in treatment-naive metastatic NSCLC with the highest PD-L1 expression levels, establishing a second first-line monotherapy immunotherapy option.

[3]

Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer

Journal of Clinical Oncology (2018)

Analysis demonstrating the predictive value of TMB for immunotherapy benefit in lung cancers, supporting prospective TMB assessment as a complement to PD-L1 in treatment selection across NSCLC and SCLC.

🏆Awards & Recognition 奖项与荣誉

🏆ESMO Presidency (2018–2020)
🏆IASLC Paul A. Bunn Jr. Scientific Award
🏆Swiss Cancer League Excellence in Cancer Research Award
🏆ESMO Lifetime Achievement Award in Thoracic Oncology

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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