Siamak Daneshmand
西亚马克·达内什曼德
MD
Professor of Urology; Director, Urologic Oncology Fellowship泌尿外科教授暨泌尿肿瘤学奖学金主任
👥Biography 个人简介
Preeminent surgical oncologist and NMIBC specialist at USC, Dr. Daneshmand leads landmark BCG-unresponsive NMIBC trials including SWOG S1602 (CISTO study) and has advanced intravesical photodynamic therapy and novel drug delivery systems to preserve the bladder in high-risk patients.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BCG-Unresponsive NMIBC Clinical Trials
Led SWOG S1602 and multiple cooperative group trials of novel intravesical agents for BCG-unresponsive NMIBC, providing bladder-preserving treatment options and contributing to FDA approvals of nadofaragene firadenovec and other agents.
Enhanced Drug Delivery for NMIBC
Developed and clinically validated the Synergo thermochemotherapy system and other heat-activated intravesical drug delivery platforms, improving intravesical mitomycin efficacy for NMIBC recurrence prevention.
Representative Works 代表性著作
Efficacy and Safety of Nadofaragene Firadenovec for BCG-Unresponsive Non–Muscle-Invasive Bladder Cancer (ADSTILADRIN Phase III)
Journal of Clinical Oncology (2023)
Pivotal trial demonstrating nadofaragene firadenovec achieved durable complete responses in BCG-unresponsive carcinoma in situ, supporting FDA approval.
Phase III Trial of Intravesical Gemcitabine versus Mitomycin C in Recurrent NMIBC
European Urology (2021)
Comparative trial informing choice of second-line intravesical chemotherapy agents for recurrent non-muscle-invasive bladder cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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