E. Shelley Hwang
谢利·黄
MD, MPH
Chief of Breast Surgery; Mary and Deryl Hart Distinguished Professor of Surgery乳腺外科主任；Mary and Deryl Hart特聘外科教授
👥Biography 个人简介
Shelley Hwang is a leading authority on DCIS biology and surgical de-escalation. She directs landmark trials studying active surveillance for low-risk DCIS, oncoplastic reconstruction, and the biological underpinnings of breast cancer progression, challenging established surgical dogma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DCIS Active Surveillance
Leads COMET, a randomized trial evaluating active surveillance vs. standard guideline care for low-risk DCIS, a paradigm-challenging de-escalation study.
DCIS Biology
Produced foundational research on the molecular heterogeneity of DCIS, identifying low-risk subtypes that may not require immediate surgical intervention.
Oncoplastic Surgery Education
Advanced oncoplastic surgical techniques at Duke, integrating reconstruction with breast conservation to improve cosmesis without compromising oncologic safety.
Representative Works 代表性著作
COMET Trial: Comparison of Operative versus Monitoring and Endocrine Therapy for Low-Risk DCIS
JAMA Oncology (2022)
Reported preliminary results of the landmark COMET trial comparing active surveillance to surgery for low-risk DCIS.
Biological heterogeneity of ductal carcinoma in situ: implications for treatment
The Lancet Oncology (2019)
Comprehensive review of DCIS biology informing risk stratification and individualized management strategies.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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