Sergio A. Quezada
塞尔希奥·克萨达
PhD
Professor of Tumour Immunology; Head, Immune Regulation and Tumour Immunotherapy Lab肿瘤免疫学教授；免疫调节与肿瘤免疫治疗实验室主任
👥Biography 个人简介
Sergio Quezada at UCL is a leading European cancer immunologist specializing in regulatory T cells and checkpoint biology. His mechanistic work on how Tregs and CTLA-4 enforce tumor immune escape, and how anti-CTLA-4 depletes intratumoral Tregs via ADCC, has provided critical insights into checkpoint immunotherapy mechanisms and resistance.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CTLA-4 Blockade Depletes Intratumoral Tregs
Demonstrated that anti-CTLA-4 (ipilimumab) exerts anti-tumor activity partly by depleting FOXP3+ Tregs within the tumor microenvironment via Fc-mediated ADCC, explaining differential efficacy and informing next-generation antibody engineering.
Treg Functional States in Tumor Immune Escape
Characterized distinct functional states and transcriptional programs of tumor-infiltrating Tregs, showing how highly activated Tregs suppress effector T cells and create an immunosuppressive niche that promotes tumor escape.
Combination CTLA-4 and PD-1 Synergy Mechanisms
Elucidated mechanistic basis for synergy between CTLA-4 and PD-1 blockade in preclinical models, linking Treg depletion with relief of T cell exhaustion and informing clinical combination checkpoint strategies.
Representative Works 代表性著作
CTLA-4 control over Foxp3+ regulatory T cell function
Science (2011)
Showed that CTLA-4 on Tregs is required for their suppressive capacity and that anti-CTLA-4 antibodies deplete tumor-infiltrating Tregs, linking CTLA-4 biology directly to immunotherapy mechanism.
Intratumoral Foxp3+ regulatory T cells and anti-CTLA-4 treatment
Journal of Clinical Investigation (2006)
Seminal study showing that anti-CTLA-4 antibody treatment reduces intratumoral Tregs and that Treg depletion is a key component of ipilimumab efficacy in solid tumors.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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