Federico Cappuzzo
费德里科·卡普佐
MD
Head, Medical Oncology内科肿瘤学负责人
👥Biography 个人简介
Federico Cappuzzo is a leading lung cancer oncologist who made early key contributions to defining EGFR amplification and FISH-based biomarker testing in NSCLC. His IPASS biomarker analyses established that EGFR mutation rather than amplification predicts gefitinib benefit, reshaping global lung cancer biomarker testing standards. Cappuzzo has led European and Italian studies characterizing emerging NSCLC biomarkers including HER2 mutations, MET exon 14 skipping, RET fusions, and NTRK fusions, contributing to the dense biomarker-driven treatment landscape in advanced NSCLC. His work spans academic discovery and clinical guideline development.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
EGFR Biomarker Clarification
Through IPASS biomarker analyses, demonstrated that EGFR mutation status rather than EGFR amplification by FISH predicts gefitinib benefit, fundamentally reshaping global EGFR testing recommendations for NSCLC.
Emerging NSCLC Biomarker Characterization
Characterized HER2 mutations, MET exon 14 skipping, and RET fusions as actionable NSCLC biomarkers through Italian multicenter programs, contributing to comprehensive NGS panel adoption in lung cancer.
Representative Works 代表性著作
Erlotinib as Maintenance Therapy in Advanced Non-Small-Cell Lung Cancer: A Multicentre, Randomised, Placebo-Controlled Phase 3 Study
Lancet Oncology (2010)
SATURN trial establishing erlotinib maintenance in EGFR-selected NSCLC.
EGFR Gene Copy Number and Clinical Outcome of Patients Treated with Gefitinib
Journal of the National Cancer Institute (2005)
Characterization of EGFR biomarker testing methods in NSCLC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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留下邮箱，当我们发布与 Federico Cappuzzo（IRCCS Regina Elena National Cancer Institute, Rome）相关的新研究或访谈时，我们会通知你。
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