Sandro Pignata
桑德罗·皮尼亚塔
MD, PhD
Director, Clinical Trials Unit; Head, Uro-Gynecological Oncology Department临床试验部主任；泌尿妇科肿瘤学部主任
👥Biography 个人简介
Sandro Pignata is Director of the Clinical Trials Unit at the Istituto Nazionale dei Tumori in Naples and a leading figure in Italian and international ovarian cancer research. He co-chairs the MITO (Multicentre Italian Trials in Ovarian Cancer) group and has been a principal investigator in numerous AGO-OVAR and MITO trials evaluating chemotherapy optimization, platinum re-challenge, and PARP inhibitor strategies, shaping European treatment guidelines.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
MITO Trial Series: Chemotherapy Optimization in Ovarian Cancer
Led the MITO series of multicenter Italian trials (MITO-2, MITO-7, MITO-16) evaluating carboplatin/pegylated liposomal doxorubicin, weekly paclitaxel, and targeted combinations, providing key evidence for chemotherapy optimization in recurrent and first-line ovarian cancer.
Platinum Re-challenge and Maintenance Strategies
Investigated criteria for platinum re-challenge in recurrent ovarian cancer and PARP inhibitor maintenance in the AGO-OVAR and MITO frameworks, establishing evidence base for sequencing and maintenance approaches in European practice.
Representative Works 代表性著作
MITO-7: Carboplatin Plus Weekly Paclitaxel Versus the Standard Schedule in Advanced Ovarian Cancer
Journal of Clinical Oncology (2014)
Phase III MITO-7 trial showing weekly carboplatin/paclitaxel improved toxicity profile and offered efficacy comparable to standard dosing in advanced ovarian cancer.
Randomized Phase III Trial of Carboplatin Plus Paclitaxel vs Carboplatin Plus Doxorubicin in Recurrent Ovarian Cancer (MITO-2)
Journal of Clinical Oncology (2011)
MITO-2 established carboplatin/pegylated liposomal doxorubicin as a valid alternative to carboplatin/paclitaxel in recurrent platinum-sensitive ovarian cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
关注 桑德罗·皮尼亚塔 的研究动态
Follow Sandro Pignata's research updates
留下邮箱，当我们发布与 Sandro Pignata（Istituto Nazionale dei Tumori, Naples）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment