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clinical / clinicalDREAMM-2, belantamab mafodotin, BCMA-targeted ADC

Sagar Lonial

萨加尔·洛尼亚尔

MD, FACP

🏢Emory University Winship Cancer Institute(埃默里大学温希普癌症研究所)🌐USA

Chief Medical Officer, Winship Cancer Institute; Anne and Bernard Gray Family Chair in Cancer; Professor and Chair, Department of Hematology and Medical Oncology, Emory University School of Medicine温希普癌症研究所首席医疗官;Anne and Bernard Gray家族癌症讲席;埃默里大学医学院血液学与医学肿瘤系教授兼主任

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Sagar Lonial, MD, FACP is Chief Medical Officer of Winship Cancer Institute, Professor and Chair of the Department of Hematology and Medical Oncology at Emory University School of Medicine, and holds the Anne and Bernard Gray Family Chair in Cancer. He is one of the preeminent myeloma clinical investigators in the United States, recognized above all for his leadership in the DREAMM-2 trial — the pivotal phase II study of belantamab mafodotin (GSK2857916), an anti-BCMA antibody-drug conjugate, which demonstrated clinically meaningful single-agent activity in heavily pretreated patients refractory to proteasome inhibitors, IMiDs, and daratumumab, leading to FDA accelerated approval of belantamab mafodotin in 2020 as the first BCMA-targeted ADC. Beyond DREAMM-2, Dr. Lonial has been deeply involved in the clinical development of elotuzumab (anti-SLAMF7), contributing to the ELOQUENT-2 trial and helping define its role in myeloma combinations. His laboratory and clinical research span BCMA biology, myeloma cell signaling, the immunological basis of anti-myeloma therapy, and novel agent combinations. He has authored more than 400 peer-reviewed publications, serves on the Board of Directors of the American Society of Hematology, and is a frequent invited lecturer at major oncology meetings worldwide.

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🧪Research Fields 研究领域

DREAMM-2 Trial — Belantamab Mafodotin (Anti-BCMA ADC) in Relapsed/Refractory MyelomaDREAMM-2试验——贝兰他单抗马法多汀(抗BCMA ADC)治疗复发/难治性骨髓瘤
BCMA as a Therapeutic Target — ADC, CAR-T, and Bispecific Antibody LandscapeBCMA作为治疗靶点——ADC、CAR-T与双特异性抗体格局
Elotuzumab (Anti-SLAMF7) Clinical Development依罗妥珠单抗(抗SLAMF7)临床开发
Novel Agent Combinations and Sequencing in Relapsed/Refractory Myeloma复发/难治性骨髓瘤新型药物联合与序贯策略
Myeloma Disease Biology and Genomic Profiling骨髓瘤疾病生物学与基因组谱分析

🎓Key Contributions 主要贡献

DREAMM-2 — First BCMA-Targeted ADC Approval in Myeloma

Led the DREAMM-2 phase II trial (Lancet Oncology 2020; n=196) of single-agent belantamab mafodotin in triple-class refractory myeloma, demonstrating an ORR of 31% (2.5 mg/kg cohort) with a median PFS of 2.8 months and median OS of 13.7 months in a highly refractory population — achieving FDA accelerated approval in August 2020 as the first BCMA-directed therapy of any class approved for myeloma and opening the BCMA therapeutic era.

Elotuzumab Clinical Development (ELOQUENT Trials)

Served as a key clinical investigator for elotuzumab, an anti-SLAMF7 immunostimulatory antibody, contributing to the ELOQUENT-2 phase III trial (NEJM 2015) demonstrating improved PFS for elotuzumab-Rd versus Rd in relapsed myeloma, leading to FDA approval of elotuzumab and establishing SLAMF7 as a validated myeloma therapeutic target.

BCMA Biology and Multi-Modality Target Exploitation

Published extensively on BCMA (B-cell maturation antigen) biology, surface expression, shedding mechanisms, and the rationale for targeting BCMA with ADCs, CAR-T cells, and bispecific antibodies. His comparative analyses have helped define the positioning of belantamab mafodotin, ide-cel, ciltacabtagene autoleucel, and teclistamab across the myeloma treatment continuum.

Myeloma Combination Regimen Optimization

Contributed to multiple clinical investigations evaluating novel triplets and quadruplets in relapsed/refractory myeloma — including carfilzomib-based regimens, next-generation IMiD combinations, and novel immunotherapy pairings — consistently advancing the evidence base guiding treatment selection for patients with multiply relapsed disease.

Representative Works 代表性著作

[1]

Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2)

The Lancet Oncology (2020)

Pivotal DREAMM-2 phase II trial of belantamab mafodotin in triple-class refractory myeloma, demonstrating clinically meaningful ORR and leading to FDA accelerated approval of the first BCMA-targeted ADC.

[2]

Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma (ELOQUENT-2)

New England Journal of Medicine (2015)

Phase III ELOQUENT-2 trial demonstrating elotuzumab-Rd improved PFS vs. Rd in relapsed myeloma, leading to FDA approval of elotuzumab.

[3]

Multiple myeloma: 2022 update on diagnosis, risk stratification, and management

American Journal of Hematology (2022)

Comprehensive annual update review covering the rapidly evolving landscape of myeloma diagnosis and treatment, widely cited as a clinical reference.

[4]

Anti-BCMA therapy in multiple myeloma: the booming landscape

Blood (2022)

Review synthesizing the ADC, CAR-T, and bispecific antibody BCMA-targeting landscape in myeloma and providing a framework for clinical positioning.

🏆Awards & Recognition 奖项与荣誉

🏆ASH Ham-Wasserman Lecture (nominated)
🏆ASCO Conquer Cancer Foundation Grant Award
🏆Winship Cancer Institute Director's Award for Clinical Excellence
🏆Multiple Myeloma Research Foundation Senior Research Award
🏆American Society of Hematology Board of Directors Member

📄Data Sources 数据来源

Last updated: 2026-04-06 | All information from publicly available academic sources

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