Sagar Lonial
萨加尔·洛尼亚尔
MD, FACP
Chief Medical Officer, Winship Cancer Institute; Anne and Bernard Gray Family Chair in Cancer; Professor and Chair, Department of Hematology and Medical Oncology, Emory University School of Medicine温希普癌症研究所首席医疗官;Anne and Bernard Gray家族癌症讲席;埃默里大学医学院血液学与医学肿瘤系教授兼主任
👥Biography 个人简介
Sagar Lonial, MD, FACP is Chief Medical Officer of Winship Cancer Institute, Professor and Chair of the Department of Hematology and Medical Oncology at Emory University School of Medicine, and holds the Anne and Bernard Gray Family Chair in Cancer. He is one of the preeminent myeloma clinical investigators in the United States, recognized above all for his leadership in the DREAMM-2 trial — the pivotal phase II study of belantamab mafodotin (GSK2857916), an anti-BCMA antibody-drug conjugate, which demonstrated clinically meaningful single-agent activity in heavily pretreated patients refractory to proteasome inhibitors, IMiDs, and daratumumab, leading to FDA accelerated approval of belantamab mafodotin in 2020 as the first BCMA-targeted ADC. Beyond DREAMM-2, Dr. Lonial has been deeply involved in the clinical development of elotuzumab (anti-SLAMF7), contributing to the ELOQUENT-2 trial and helping define its role in myeloma combinations. His laboratory and clinical research span BCMA biology, myeloma cell signaling, the immunological basis of anti-myeloma therapy, and novel agent combinations. He has authored more than 400 peer-reviewed publications, serves on the Board of Directors of the American Society of Hematology, and is a frequent invited lecturer at major oncology meetings worldwide.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DREAMM-2 — First BCMA-Targeted ADC Approval in Myeloma
Led the DREAMM-2 phase II trial (Lancet Oncology 2020; n=196) of single-agent belantamab mafodotin in triple-class refractory myeloma, demonstrating an ORR of 31% (2.5 mg/kg cohort) with a median PFS of 2.8 months and median OS of 13.7 months in a highly refractory population — achieving FDA accelerated approval in August 2020 as the first BCMA-directed therapy of any class approved for myeloma and opening the BCMA therapeutic era.
Elotuzumab Clinical Development (ELOQUENT Trials)
Served as a key clinical investigator for elotuzumab, an anti-SLAMF7 immunostimulatory antibody, contributing to the ELOQUENT-2 phase III trial (NEJM 2015) demonstrating improved PFS for elotuzumab-Rd versus Rd in relapsed myeloma, leading to FDA approval of elotuzumab and establishing SLAMF7 as a validated myeloma therapeutic target.
BCMA Biology and Multi-Modality Target Exploitation
Published extensively on BCMA (B-cell maturation antigen) biology, surface expression, shedding mechanisms, and the rationale for targeting BCMA with ADCs, CAR-T cells, and bispecific antibodies. His comparative analyses have helped define the positioning of belantamab mafodotin, ide-cel, ciltacabtagene autoleucel, and teclistamab across the myeloma treatment continuum.
Myeloma Combination Regimen Optimization
Contributed to multiple clinical investigations evaluating novel triplets and quadruplets in relapsed/refractory myeloma — including carfilzomib-based regimens, next-generation IMiD combinations, and novel immunotherapy pairings — consistently advancing the evidence base guiding treatment selection for patients with multiply relapsed disease.
Representative Works 代表性著作
Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2)
The Lancet Oncology (2020)
Pivotal DREAMM-2 phase II trial of belantamab mafodotin in triple-class refractory myeloma, demonstrating clinically meaningful ORR and leading to FDA accelerated approval of the first BCMA-targeted ADC.
Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma (ELOQUENT-2)
New England Journal of Medicine (2015)
Phase III ELOQUENT-2 trial demonstrating elotuzumab-Rd improved PFS vs. Rd in relapsed myeloma, leading to FDA approval of elotuzumab.
Multiple myeloma: 2022 update on diagnosis, risk stratification, and management
American Journal of Hematology (2022)
Comprehensive annual update review covering the rapidly evolving landscape of myeloma diagnosis and treatment, widely cited as a clinical reference.
Anti-BCMA therapy in multiple myeloma: the booming landscape
Blood (2022)
Review synthesizing the ADC, CAR-T, and bispecific antibody BCMA-targeting landscape in myeloma and providing a framework for clinical positioning.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-04-06 | All information from publicly available academic sources
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