Saby George
萨比·乔治
MD, FACP
Professor of Oncology; Director, Genitourinary Oncology Program肿瘤学教授；泌尿肿瘤项目主任
👥Biography 个人简介
Saby George, MD FACP is Professor of Oncology and Director of the Genitourinary Oncology Program at Roswell Park Comprehensive Cancer Center. He is a recognized national leader in the clinical management of non-clear cell renal cell carcinoma subtypes, including papillary, chromophobe, and translocation RCC. His work on MET-targeted therapy and rare RCC histologies has defined treatment strategies for patients whose disease is underserved by standard clear-cell-focused trials.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Non-Clear Cell RCC Clinical Trials and Treatment Strategies
Led and contributed to multiple clinical trials specifically designed for non-clear cell RCC subtypes, generating prospective evidence that informed treatment algorithms for papillary, chromophobe, and other rare histologies that are historically excluded from landmark trials.
MET Pathway Inhibition in Papillary RCC
Conducted clinical investigations of MET inhibitors including foretinib and cabozantinib in MET-driven papillary type 1 RCC, establishing proof-of-concept for MET-targeted therapy and contributing to biomarker-selected trial designs in this rare subtype.
Rare Genitourinary Tumors Program Development
Built one of the nation's leading rare genitourinary tumor programs at Roswell Park, specializing in translocation RCC, collecting duct carcinoma, renal medullary carcinoma, and other uncommon kidney cancer histologies, improving access to specialized care and clinical trials.
Representative Works 代表性著作
Multicenter Phase II Trial of Foretinib in Patients with Papillary Renal Cell Carcinoma
Journal of Clinical Oncology (2013)
Phase II trial of foretinib (MET/VEGFR inhibitor) in papillary RCC demonstrating responses linked to germline MET mutations, establishing MET as a therapeutic target and informing subsequent trials in hereditary papillary RCC.
Treatment Patterns and Outcomes in Non-Clear Cell Renal Cell Carcinoma in the Targeted Therapy Era
Cancer (2018)
Large retrospective analysis characterizing real-world treatment outcomes across non-clear cell RCC subtypes, identifying subtype-specific prognostic factors and informing evidence-based treatment selection in the absence of prospective trial data.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Brian I. Rini
Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
Robert J. Motzer
Memorial Sloan Kettering Cancer Center
Toni K. Choueiri
Dana-Farber Cancer Institute, Harvard Medical School
Sumanta Pal
City of Hope Comprehensive Cancer Center
关注 萨比·乔治 的研究动态
Follow Saby George's research updates
留下邮箱，当我们发布与 Saby George（Roswell Park Comprehensive Cancer Center）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment