Robert D. Schreiber
罗伯特·施赖贝尔
PhD
Alumni Endowed Professor of Pathology and Immunology; Director, Center for Human Immunology and Immunotherapy Programs病理学与免疫学终身讲席教授；人类免疫学与免疫治疗项目中心主任
👥Biography 个人简介
Robert Schreiber is a pioneer of cancer immunology at Washington University St. Louis. He formulated the cancer immunoediting hypothesis—encompassing elimination, equilibrium, and escape—fundamentally redefining how the immune system shapes tumor evolution. His work on IFN-gamma and immunosurveillance underpins modern checkpoint immunotherapy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Cancer Immunoediting Theory
Developed the three-phase cancer immunoediting model (elimination, equilibrium, escape) with Lloyd Old, providing the foundational framework explaining how immune pressure both restrains tumors and selects for immune-evasive variants, published in Nature 2004.
IFN-gamma in Tumor Immunosurveillance
Demonstrated through gene-targeted mouse models that IFN-gamma receptor signaling on tumor cells is essential for immune-mediated tumor rejection, establishing IFN-gamma as a critical mediator of cancer immunosurveillance.
Neoantigen-Based Immunotherapy
Pioneered personalized neoantigen vaccine strategies, showing that mutation-derived neoantigens are primary targets of tumor-specific T cells and can be exploited therapeutically to overcome immune escape.
Representative Works 代表性著作
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
Science (2011)
Landmark review synthesizing the cancer immunoediting framework and its mechanistic basis, which became a cornerstone reference for the checkpoint immunotherapy era.
Immunological Editing of Cancer
Nature (2004)
Original article establishing the three-phase cancer immunoediting model with experimental evidence from IFN-gamma-deficient and RAG-deficient mouse systems.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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