Rameen Beroukhim
拉敏·贝鲁希姆
MD, PhD
Associate Professor of Medicine, Harvard Medical School哈佛医学院医学副教授
👥Biography 个人简介
Computational and translational cancer genomicist specializing in copy number alterations and somatic mutations across cancer types. His GISTIC algorithm is a standard tool for identifying cancer driver genomic regions.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Copy Number Analysis
Developed GISTIC and related algorithms that identify statistically significant amplifications and deletions across cancer genomes, used in virtually all cancer genomics studies.
Pan-Cancer Genomics
Led comprehensive analyses of somatic copy number alterations across thousands of cancer genomes, defining recurrent driver events.
Glioblastoma Genomics
Contributed to detailed genomic characterization of glioblastoma, identifying amplified oncogenes and deleted tumor suppressors as therapeutic targets.
Representative Works 代表性著作
The landscape of somatic copy-number alteration across human cancers
Nature (2010)
Pan-cancer analysis of copy number alterations in 3,131 cancer specimens identifying 158 regions with significant driver events.
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma
PNAS (2007)
Introduced GISTIC algorithm for identifying cancer driver copy number events, now a standard bioinformatics tool.
Amplification of focal regions of chromosome 4q12 in human cancers
Nature Genetics (2009)
Identified a focal amplification harboring PDGFRA with therapeutic implications across cancer types.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Mary-Claire King
University of Washington
Kenneth Offit
Memorial Sloan Kettering Cancer Center
Judy Garber
Dana-Farber Cancer Institute
Barbara Biesecker
RTI International / NHGRI
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