Mary-Claire King
玛丽-克莱尔·金
PhD
Professor of Genome Sciences and Medicine基因组科学与医学教授
👥Biography 个人简介
Pioneering geneticist who discovered the BRCA1 gene locus in 1990, revolutionizing hereditary breast cancer research. Her work linking genetics to breast cancer risk transformed oncology and enabled preventive strategies for millions of women worldwide.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BRCA1 Discovery
Identified chromosome 17q21 as the location of BRCA1 in 1990, establishing the hereditary basis of breast-ovarian cancer syndrome and founding a new era of cancer genetics.
Population Genetics
Demonstrated that BRCA1/2 mutations occur across diverse populations, advocating for universal population-based genetic screening programs.
Representative Works 代表性著作
Linkage of early-onset familial breast cancer to chromosome 17q21
Science (1990)
Landmark paper mapping BRCA1 locus, one of the most consequential discoveries in cancer genetics history.
Establishing a hereditary basis for breast cancer
New England Journal of Medicine (2014)
Comprehensive review advocating population-based BRCA screening, influencing international screening guidelines.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Kenneth Offit
Memorial Sloan Kettering Cancer Center
Judy Garber
Dana-Farber Cancer Institute
Barbara Biesecker
RTI International / NHGRI
Bert Vogelstein
Johns Hopkins University School of Medicine
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