Priya Kumthekar
普里亚·库姆塔卡尔
MD
Associate Professor of Neurology; Director, Neuro-Oncology Clinical Program神经肿瘤临床项目主任、副教授
👥Biography 个人简介
Priya Kumthekar is a pioneering neuro-oncologist at Northwestern specializing in blood-brain barrier drug delivery for GBM. She led the first-in-human trial of RNA-lipid nanoparticles for GBM and champions innovative delivery technologies to improve CNS tumor therapy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Blood-Brain Barrier Drug Delivery
Led clinical translation of lipid nanoparticle systems for CNS delivery, opening new avenues for GBM therapy beyond traditional chemotherapy.
RNA Nanoparticle Therapy
Conducted first-in-human trial of NU-0129, a gold nanoparticle siRNA targeting Bcl2L12 in recurrent GBM, demonstrating CNS penetration.
GBM Clinical Research
Designed and led multiple phase I/II trials evaluating novel agents for newly diagnosed and recurrent GBM at Northwestern.
Representative Works 代表性著作
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma
Science Translational Medicine (2021)
Demonstrated CNS penetration and target gene silencing of gold nanoparticle-siRNA in GBM patients, proof-of-principle for RNA nanotherapy.
Phase II study of temozolomide and lapatinib for recurrent glioblastoma patients
Neuro-Oncology (2016)
Evaluated dual EGFR/HER2 blockade with lapatinib plus temozolomide in recurrent GBM, informing BBB-penetrant kinase inhibitor strategy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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UCLA Health / David Geffen School of Medicine
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Michael Weller
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Susan M. Chang
University of California San Francisco (UCSF)
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