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clinical / clinicalT-cell lymphoma, PTCL, brentuximab vedotin, cutaneous lymphoma, ECHELON-2

Pier Luigi Zinzani

皮尔·路易吉·津扎尼

MD, PhD

🏢University of Bologna / IRCCS Azienda Ospedaliero-Universitaria di Bologna(博洛尼亚大学 / 博洛尼亚大学医院)🌐Italy

Professor of Hematology; Director, Institute of Hematology "L. e A. Seràgnoli"血液学教授;"L. e A. Seràgnoli"血液学研究所所长

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Pier Luigi Zinzani, MD, PhD is Professor of Hematology and Director of the Institute of Hematology "L. e A. Seràgnoli" at the University of Bologna and IRCCS University Hospital, one of Europe's leading hematology centers. He is internationally recognized as one of the world's foremost experts in T-cell lymphomas and is a key contributor to the ECHELON-2 trial — the landmark phase III study published in The Lancet (2019) demonstrating that brentuximab vedotin plus CHP (A+CHP) significantly improved progression-free and overall survival compared with standard CHOP in patients with previously untreated CD30-positive peripheral T-cell lymphoma (PTCL), resulting in FDA and EMA approval of A+CHP as the new frontline standard for this disease. Dr. Zinzani has authored more than 600 peer-reviewed publications covering the full spectrum of mature lymphoid neoplasms, with particular depth in cutaneous T-cell lymphoma, natural killer/T-cell lymphoma, anaplastic large cell lymphoma, and aggressive B-cell lymphomas. He serves as president of the Italian Lymphoma Foundation (FIL), leading a national cooperative group network that has generated numerous pivotal trials in T-cell and B-cell lymphoma. He is also a recognized authority on novel agents in relapsed lymphoma, including PI3K inhibitors, PD-1 checkpoint inhibitors, and antibody-drug conjugates.

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🧪Research Fields 研究领域

Peripheral T-Cell Lymphoma (PTCL) — Biology and Systemic Treatment外周T细胞淋巴瘤(PTCL)——生物学与系统治疗
ECHELON-2 Trial — Brentuximab Vedotin plus CHP in CD30-Positive PTCLECHELON-2试验——维布妥昔单抗联合CHP在CD30阳性PTCL中的应用
Cutaneous T-Cell Lymphoma (CTCL) — Mycosis Fungoides and Sézary Syndrome皮肤T细胞淋巴瘤(CTCL)——蕈样肉芽肿与塞扎里综合征
Novel Agents in Relapsed/Refractory T-Cell and B-Cell Lymphomas复发/难治性T细胞和B细胞淋巴瘤新型药物
Italian Lymphoma Foundation (FIL) Clinical Trial Leadership意大利淋巴瘤基金会(FIL)临床试验领导

🎓Key Contributions 主要贡献

ECHELON-2 Trial — A+CHP as New Frontline Standard in CD30-Positive PTCL

Was a major contributing investigator to the phase III ECHELON-2 trial (Lancet 2019) demonstrating that brentuximab vedotin plus CHP improved progression-free survival (HR 0.71) and overall survival (HR 0.66) versus CHOP in previously untreated CD30-positive PTCL, establishing A+CHP as the new international standard of care for this aggressive disease and achieving the first OS benefit over CHOP in T-cell lymphoma.

Italian Lymphoma Foundation (FIL) — National Cooperative Group Leadership

Serves as president of the Fondazione Italiana Linfomi (FIL), coordinating a network of more than 100 Italian centers conducting investigator-initiated trials in lymphoma, including studies of PD-1 inhibitors in primary mediastinal B-cell lymphoma, novel combinations in PTCL, and CAR-T cell therapy access programs across Italian oncology centers.

Cutaneous T-Cell Lymphoma — Novel Systemic and Skin-Directed Therapies

Conducted seminal work in mycosis fungoides (MF) and Sézary syndrome (SS), evaluating mogamulizumab (anti-CCR4), vorinostat, romidepsin, bexarotene, and novel combination regimens, and contributing to the understanding of disease progression biomarkers, staging accuracy, and skin-directed vs. systemic therapy sequencing in advanced cutaneous T-cell lymphoma.

Novel Agent Development Across Lymphoma Subtypes

Has been a principal investigator in phase I/II trials of ibrutinib in marginal zone lymphoma, pembrolizumab in primary mediastinal B-cell lymphoma and Hodgkin lymphoma, and loncastuximab tesirine in relapsed DLBCL, contributing to multiple regulatory approvals and substantially expanding the therapeutic armamentarium for relapsed/refractory lymphomas.

Representative Works 代表性著作

[1]

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2)

The Lancet (2019)

Landmark phase III ECHELON-2 trial showing A+CHP improves PFS and OS versus CHOP in CD30-positive PTCL, establishing the new frontline treatment standard.

[2]

Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC)

Lancet Oncology (2018)

Phase III MAVORIC trial demonstrating mogamulizumab superiority over vorinostat in relapsed CTCL, contributing to FDA approval of mogamulizumab.

[3]

Pembrolizumab in relapsed or refractory primary mediastinal large B-cell lymphoma

Journal of Clinical Oncology (2019)

Phase II KEYNOTE-170 study demonstrating significant activity of pembrolizumab in relapsed/refractory primary mediastinal B-cell lymphoma, supporting regulatory approval.

[4]

Peripheral T-cell lymphoma: ESMO Clinical Practice Guidelines

Annals of Oncology (2015)

ESMO clinical practice guidelines for PTCL management co-authored by Dr. Zinzani, covering diagnosis, staging, frontline therapy, and relapsed disease management.

🏆Awards & Recognition 奖项与荣誉

🏆Fondazione Italiana Linfomi (FIL) President
🏆EHA Scientific Committee, T-Cell Lymphomas
🏆ESMO Faculty, Haematological Malignancies
🏆Italian Society of Haematology Distinguished Faculty Award
🏆International T-Cell Lymphoma Forum Steering Committee

📄Data Sources 数据来源

Last updated: 2026-04-06 | All information from publicly available academic sources

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