Pier Luigi Zinzani
皮尔·路易吉·津扎尼
MD, PhD
Professor of Hematology; Director, Institute of Hematology "L. e A. Seràgnoli"血液学教授;"L. e A. Seràgnoli"血液学研究所所长
👥Biography 个人简介
Pier Luigi Zinzani, MD, PhD is Professor of Hematology and Director of the Institute of Hematology "L. e A. Seràgnoli" at the University of Bologna and IRCCS University Hospital, one of Europe's leading hematology centers. He is internationally recognized as one of the world's foremost experts in T-cell lymphomas and is a key contributor to the ECHELON-2 trial — the landmark phase III study published in The Lancet (2019) demonstrating that brentuximab vedotin plus CHP (A+CHP) significantly improved progression-free and overall survival compared with standard CHOP in patients with previously untreated CD30-positive peripheral T-cell lymphoma (PTCL), resulting in FDA and EMA approval of A+CHP as the new frontline standard for this disease. Dr. Zinzani has authored more than 600 peer-reviewed publications covering the full spectrum of mature lymphoid neoplasms, with particular depth in cutaneous T-cell lymphoma, natural killer/T-cell lymphoma, anaplastic large cell lymphoma, and aggressive B-cell lymphomas. He serves as president of the Italian Lymphoma Foundation (FIL), leading a national cooperative group network that has generated numerous pivotal trials in T-cell and B-cell lymphoma. He is also a recognized authority on novel agents in relapsed lymphoma, including PI3K inhibitors, PD-1 checkpoint inhibitors, and antibody-drug conjugates.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ECHELON-2 Trial — A+CHP as New Frontline Standard in CD30-Positive PTCL
Was a major contributing investigator to the phase III ECHELON-2 trial (Lancet 2019) demonstrating that brentuximab vedotin plus CHP improved progression-free survival (HR 0.71) and overall survival (HR 0.66) versus CHOP in previously untreated CD30-positive PTCL, establishing A+CHP as the new international standard of care for this aggressive disease and achieving the first OS benefit over CHOP in T-cell lymphoma.
Italian Lymphoma Foundation (FIL) — National Cooperative Group Leadership
Serves as president of the Fondazione Italiana Linfomi (FIL), coordinating a network of more than 100 Italian centers conducting investigator-initiated trials in lymphoma, including studies of PD-1 inhibitors in primary mediastinal B-cell lymphoma, novel combinations in PTCL, and CAR-T cell therapy access programs across Italian oncology centers.
Cutaneous T-Cell Lymphoma — Novel Systemic and Skin-Directed Therapies
Conducted seminal work in mycosis fungoides (MF) and Sézary syndrome (SS), evaluating mogamulizumab (anti-CCR4), vorinostat, romidepsin, bexarotene, and novel combination regimens, and contributing to the understanding of disease progression biomarkers, staging accuracy, and skin-directed vs. systemic therapy sequencing in advanced cutaneous T-cell lymphoma.
Novel Agent Development Across Lymphoma Subtypes
Has been a principal investigator in phase I/II trials of ibrutinib in marginal zone lymphoma, pembrolizumab in primary mediastinal B-cell lymphoma and Hodgkin lymphoma, and loncastuximab tesirine in relapsed DLBCL, contributing to multiple regulatory approvals and substantially expanding the therapeutic armamentarium for relapsed/refractory lymphomas.
Representative Works 代表性著作
Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2)
The Lancet (2019)
Landmark phase III ECHELON-2 trial showing A+CHP improves PFS and OS versus CHOP in CD30-positive PTCL, establishing the new frontline treatment standard.
Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC)
Lancet Oncology (2018)
Phase III MAVORIC trial demonstrating mogamulizumab superiority over vorinostat in relapsed CTCL, contributing to FDA approval of mogamulizumab.
Pembrolizumab in relapsed or refractory primary mediastinal large B-cell lymphoma
Journal of Clinical Oncology (2019)
Phase II KEYNOTE-170 study demonstrating significant activity of pembrolizumab in relapsed/refractory primary mediastinal B-cell lymphoma, supporting regulatory approval.
Peripheral T-cell lymphoma: ESMO Clinical Practice Guidelines
Annals of Oncology (2015)
ESMO clinical practice guidelines for PTCL management co-authored by Dr. Zinzani, covering diagnosis, staging, frontline therapy, and relapsed disease management.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-04-06 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
关注 皮尔·路易吉·津扎尼 的研究动态
Follow Pier Luigi Zinzani's research updates
留下邮箱,当我们发布与 Pier Luigi Zinzani(University of Bologna / IRCCS Azienda Ospedaliero-Universitaria di Bologna)相关的新研究或访谈时,我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment