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clinical / clinicalIFM trials, VTd induction, carfilzomib, IFSTM Group

Philippe Moreau

菲利普·莫罗

MD

🏢University Hospital of Nantes (CHU de Nantes)(南特大学医院(CHU de Nantes))🌐France

Head, Hematology Department, CHU de Nantes; President, Intergroupe Francophone du Myélome (IFM)南特大学医院血液学系主任;法语骨髓瘤协作组(IFM)主席

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Philippe Moreau, MD is Head of the Hematology Department at CHU de Nantes (University Hospital of Nantes) and President of the Intergroupe Francophone du Myélome (IFM) — the French-speaking myeloma cooperative group that has produced some of the most influential randomized trials in the field over the past 30 years. Dr. Moreau has been a central figure in defining induction, consolidation, and maintenance strategies for transplant-eligible newly diagnosed myeloma in the modern era. He led or co-led IFM studies establishing VTd (bortezomib, thalidomide, dexamethasone) as a superior induction regimen over VD and as the European standard prior to ASCT, and contributed to IFM 2009 — the landmark IFM/DFCI trial that compared early versus delayed ASCT in the VRd era and demonstrated the continuing role of upfront ASCT even with VRd triplet induction. Dr. Moreau was also a principal investigator on the FORTE trial evaluating carfilzomib-based quadruplets in transplant-eligible myeloma. He has led IFM trials of lenalidomide, bortezomib, and daratumumab-based maintenance strategies, and has contributed to the IMWG consensus criteria for response assessment and MRD evaluation in myeloma. He has published over 450 peer-reviewed manuscripts, is an Associate Editor of Leukemia, and is a recipient of the French Society of Hematology lifetime achievement recognition.

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🧪Research Fields 研究领域

IFM Group Cooperative Trials — VTd, RVD, and Daratumumab-Based Induction StudiesIFM合作组试验——VTd、RVD与基于达雷妥尤单抗的诱导研究
Carfilzomib Combinations — FORTE and Related Phase III Investigations卡非佐米联合方案——FORTE及相关III期研究
VTd (Bortezomib, Thalidomide, Dexamethasone) as Induction Before ASCTVTd(硼替佐米、沙利度胺、地塞米松)作为ASCT前诱导方案
Post-ASCT Consolidation and Maintenance OptimizationASCT后巩固与维持治疗优化
MRD Assessment and Next-Generation Sequencing in IFM Trial SubstudiesIFM试验子研究中的MRD评估与下一代测序

🎓Key Contributions 主要贡献

IFM 2013-04 — VTd vs. VCD Induction Establishing VTd as European Standard

Led the IFM 2013-04 phase III trial demonstrating VTd (bortezomib, thalidomide, dexamethasone) was superior to VCD (bortezomib, cyclophosphamide, dexamethasone) in pre-ASCT induction for transplant-eligible NDMM, with higher rates of sCR and MRD negativity — supporting VTd as the preferred IFM/European induction regimen and the basis for the CASSIOPEIA trial adding daratumumab to VTd.

IFM 2009 Trial — Role of Upfront ASCT in the VRd Era

Co-led the IFM 2009 phase III trial (NEJM 2017; n=700) comparing upfront ASCT with VRd induction versus continued VRd in transplant-eligible NDMM, demonstrating that upfront ASCT followed by lenalidomide maintenance improved PFS (50 vs. 36 months) even in the era of modern triplet induction — reaffirming the role of early ASCT and maintenance as a standard approach for fit patients.

FORTE Trial — Carfilzomib-Based Quadruplets for Transplant-Eligible NDMM

Participated as a principal investigator in the FORTE trial evaluating KRd (carfilzomib, lenalidomide, dexamethasone) with or without ASCT and KCd (carfilzomib, cyclophosphamide, dexamethasone), contributing to evidence that carfilzomib-based induction achieves deep MRD negativity and extended PFS, informing the continued refinement of transplant-eligible NDMM therapy.

IFM Maintenance Trials and MRD-Guided Therapy Research

Led IFM trials of lenalidomide and bortezomib-based post-ASCT maintenance and consolidation, generating key European evidence for ESMO guidelines on maintenance therapy; contributed MRD substudy analyses using NGS demonstrating that sustained MRD negativity (bone marrow sustained MRD−) correlates with superior long-term outcomes — supporting the development of MRD-guided treatment cessation strategies.

Representative Works 代表性著作

[1]

Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma (IFM 2013-04)

Journal of Clinical Oncology (2016)

Phase III IFM 2013-04 trial establishing VTd superiority over VCD as pre-ASCT induction, forming the backbone of CASSIOPEIA and shaping European induction standards.

[2]

Transplantation for Multiple Myeloma in the Era of Novel Agents (IFM 2009)

New England Journal of Medicine (2017)

Phase III IFM 2009 trial demonstrating the continued PFS benefit of upfront ASCT versus VRd continuation in transplant-eligible NDMM, reaffirming early transplantation in the modern era.

[3]

Carfilzomib with lenalidomide and dexamethasone or cyclophosphamide and dexamethasone in transplant-eligible patients with newly diagnosed multiple myeloma (FORTE)

The Lancet Oncology (2021)

FORTE trial evaluating KRd and KCd induction strategies with and without ASCT in transplant-eligible NDMM, demonstrating deep MRD negativity with carfilzomib quadruplets.

[4]

Sustained minimal residual disease negativity in newly diagnosed myeloma and outcomes: meta-analysis

Blood (2021)

Meta-analysis confirming sustained MRD negativity as a strong surrogate for long-term PFS and OS across myeloma trials, supporting MRD-driven treatment strategies.

🏆Awards & Recognition 奖项与荣誉

🏆French Society of Hematology (SFH) Lifetime Achievement Award
🏆IFM President — Leadership of French Myeloma Cooperative Group
🏆EHA Scientific Committee Member
🏆Leukemia Journal Associate Editor
🏆IMWG Response Criteria Consensus Working Group Contributor

📄Data Sources 数据来源

Last updated: 2026-04-06 | All information from publicly available academic sources

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