Jochen Lorch
约亨·洛奇
MD
Clinical Director, Thyroid Cancer Program甲状腺癌项目临床主任
👥Biography 个人简介
Jochen Lorch is a thyroid cancer oncologist who has made significant contributions to development of immunotherapy and BRAF-targeted therapy combinations in anaplastic thyroid cancer. He led phase II studies of spartalizumab (anti-PD-1) in combination with dabrafenib and trametinib in BRAF V600E anaplastic thyroid cancer, demonstrating impressive response rates in a historically uniformly fatal disease with median survival measured in months. Lorch has also investigated lenvatinib and pembrolizumab combinations in radioiodine-refractory differentiated thyroid cancer and contributes to ATA guideline panel activities for advanced thyroid cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BRAF/MEK Plus Immunotherapy in ATC
Led trials investigating spartalizumab combined with dabrafenib/trametinib in BRAF V600E-positive anaplastic thyroid cancer, demonstrating high response rates in this previously uniformly fatal disease.
Thyroid Cancer Combination Trial Design
Designed and led innovative combination trials for advanced thyroid cancer including VEGFR/TKI plus immune checkpoint combinations, generating evidence for multimodal approaches in refractory thyroid cancer.
Representative Works 代表性著作
Combination of Dabrafenib and Trametinib for BRAF V600E-Mutant Anaplastic Thyroid Carcinoma
New England Journal of Medicine (2018)
Phase II trial of BRAF/MEK inhibitors in anaplastic thyroid cancer.
Pembrolizumab in Advanced Differentiated Thyroid Cancer
Journal of Clinical Oncology (2021)
Phase II pembrolizumab in RAI-refractory thyroid cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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