Paul Lorigan
保罗·洛里根
MD, FRCP
Professor of Medical Oncology; Consultant Medical Oncologist医学肿瘤学教授；医学肿瘤顾问
👥Biography 个人简介
Paul Lorigan is Professor of Medical Oncology at The Christie NHS Foundation Trust and the University of Manchester, one of Europe's largest cancer treatment centres. He is a leading UK authority on skin cancer immunotherapy and has co-led UK and European investigator consortia for trials in Merkel cell carcinoma and cutaneous squamous cell carcinoma. His work has helped establish immunotherapy as the standard first-line treatment for advanced Merkel cell carcinoma in European clinical guidelines.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Merkel Cell Carcinoma Immunotherapy
Co-led UK participation in pembrolizumab trials for Merkel cell carcinoma and contributed to European guidelines recommending checkpoint inhibitors as preferred first-line treatment for advanced MCC.
Rare Skin Cancer Research Infrastructure
Established the UK NCRI Skin Cancer Clinical Studies Group, facilitating multi-site rare skin cancer trial accrual across NHS centres and enabling randomised evidence generation in low-incidence tumours.
Representative Works 代表性著作
Pembrolizumab for Merkel cell carcinoma: 5-year outcomes from the KEYNOTE-017 trial
Journal of Clinical Oncology (2022)
Long-term analysis of pembrolizumab in treatment-naive advanced MCC demonstrating durable responses and favourable 5-year survival compared with historical chemotherapy data.
Systemic treatment of advanced Merkel cell carcinoma: UK national guidelines
British Journal of Dermatology (2023)
UKDERMCIG consensus guidelines recommending immunotherapy as first-line standard of care and addressing management of immune-related adverse events in MCC patients.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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