Paolo G. Casali
保罗·卡萨利
MD
Director, Sarcoma Medical Oncology Unit; Professor of Medical Oncology肉瘤内科肿瘤学单元主任；内科肿瘤学教授
👥Biography 个人简介
Paolo Casali is the head of the Sarcoma Medical Oncology Unit at the Istituto Nazionale dei Tumori in Milan and a founding architect of modern European sarcoma management. He chaired the development of ESMO clinical practice guidelines for soft tissue sarcomas and GIST over multiple editions and has been the principal investigator on numerous landmark EORTC sarcoma trials. His research spans the biology and treatment of leiomyosarcoma, retroperitoneal sarcoma multidisciplinary management, and GIST adjuvant therapy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ESMO Sarcoma Guidelines Leadership
Served as lead author and chair for multiple editions of the ESMO clinical practice guidelines for soft tissue and visceral sarcomas and for GIST, shaping European and international treatment standards across all major sarcoma subtypes.
Adjuvant Imatinib Duration in GIST
Co-led the Scandinavian Sarcoma Group / AIO trial (SSG XVIII) demonstrating that 3 years of adjuvant imatinib after resection of high-risk GIST was superior to 1 year in improving recurrence-free and overall survival, establishing the 3-year standard.
Retroperitoneal Sarcoma Multimodal Management
Led the TransAtlantic Retroperitoneal Sarcoma Working Group (TARPSWG) consensus initiatives, establishing evidence-based surgical and multidisciplinary treatment standards for the management of primary and recurrent retroperitoneal sarcoma.
Representative Works 代表性著作
Soft Tissue and Visceral Sarcomas: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up
Annals of Oncology (2022)
Authoritative European guidelines for soft tissue sarcoma management updated with latest evidence.
Adjuvant Imatinib Mesylate after Resection of Localised, Primary Gastrointestinal Stromal Tumour: A Randomised, Double-Blind, Placebo-Controlled Trial
The Lancet (2009)
ACOSOG Z9001 phase III trial establishing adjuvant imatinib benefit in resected primary GIST.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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