Nicolas Tray

Nicolas Tray, MD is Assistant Attending Physician in the Early Drug Development Service at Memorial Sloan Kettering Cancer Center and Instructor in Medicine at Weill Cornell Medicine, where he focuses on the clinical development of novel oncology agents in patients with gastrointestinal malignancies and other advanced solid tumors. Dr. Tray trained in medicine and medical oncology in Paris before joining MSK, where he completed a fellowship in experimental therapeutics and early drug development. He specializes in early-phase trial design, protocol development, and the conduct of first-in-human and dose-escalation studies, with a particular interest in integrating patient-reported outcomes (PROs) into phase I trial design to systematically capture treatment-related symptom burden, quality of life impact, and tolerability information that traditional toxicity grading scales may underreport. Dr. Tray has been instrumental in developing PRO collection infrastructure within MSK's Early Drug Development Service and has published work validating PRO tools for common phase I toxicities (fatigue, nausea, neuropathy, diarrhea), advocating for their routine incorporation as secondary or exploratory endpoints in phase I trials. He has led or co-led phase I studies targeting KRAS G12C, FGFR inhibitors, and novel immune combination regimens in gastrointestinal cancers, with an emphasis on translational biomarker co-development. Dr. Tray represents a new generation of phase I oncologists combining rigorous clinical trial methodology with patient-centered outcome research.