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clinical / clinicalbreast cancer biomarkers

Nadia Harbeck

纳迪亚·哈贝克

MD

🏢LMU University Hospital Munich, Breast Center(慕尼黑大学医院乳腺中心)🌐Germany

Professor and Head, Breast Center乳腺中心主任及教授

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h-index
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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Nadia Harbeck is a leading European breast oncologist specializing in biomarker-guided treatment selection and de-escalation strategies. She led the pivotal SUCCESS C trial and contributed to landmark studies establishing uPA/PAI-1 as the first prospectively validated protein biomarkers for chemotherapy decision-making in early breast cancer. Harbeck has been central to validation of multi-gene expression signatures including Oncotype DX and EndoPredict, particularly in intermediate-risk node-positive patients. She co-chairs the AGO Breast Committee and has shaped European guidelines for biomarker use in early breast cancer management.

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🧪Research Fields 研究领域

HER2 biomarkersHER2生物标志物
uPA/PAI-1 breast canceruPA/PAI-1乳腺癌
gene expression signatures基因表达特征
endocrine resistance biomarkers内分泌耐药生物标志物
breast cancer risk stratification乳腺癌风险分层

🎓Key Contributions 主要贡献

uPA/PAI-1 Biomarker Validation

Led prospective validation of uPA/PAI-1 protein biomarkers through the Chemo N0 trial, establishing the first prospectively validated biomarkers for chemotherapy decision-making in node-negative breast cancer.

Multi-Gene Signature Evaluation

Contributed pivotal European data on Oncotype DX and EndoPredict in intermediate-risk breast cancer, informing European guideline recommendations for gene expression profiling.

Representative Works 代表性著作

[1]

Prospective Validation of the uPA/PAI-1 Test in Early Breast Cancer

Journal of the National Cancer Institute (2013)

Definitive prospective validation of uPA/PAI-1 protein biomarkers for chemotherapy decisions.

[2]

EndoPredict Predicts Clinical Outcome of ER+/HER2- Breast Cancer Patients

Annals of Oncology (2012)

Validation of EndoPredict gene expression signature for breast cancer risk stratification.

🏆Awards & Recognition 奖项与荣誉

🏆AGO Breast Committee Award
🏆EBCC Award for Excellence in Breast Cancer Research

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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