Nadia Harbeck
纳迪亚·哈贝克
MD
Professor and Head, Breast Center乳腺中心主任及教授
👥Biography 个人简介
Nadia Harbeck is a leading European breast oncologist specializing in biomarker-guided treatment selection and de-escalation strategies. She led the pivotal SUCCESS C trial and contributed to landmark studies establishing uPA/PAI-1 as the first prospectively validated protein biomarkers for chemotherapy decision-making in early breast cancer. Harbeck has been central to validation of multi-gene expression signatures including Oncotype DX and EndoPredict, particularly in intermediate-risk node-positive patients. She co-chairs the AGO Breast Committee and has shaped European guidelines for biomarker use in early breast cancer management.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
uPA/PAI-1 Biomarker Validation
Led prospective validation of uPA/PAI-1 protein biomarkers through the Chemo N0 trial, establishing the first prospectively validated biomarkers for chemotherapy decision-making in node-negative breast cancer.
Multi-Gene Signature Evaluation
Contributed pivotal European data on Oncotype DX and EndoPredict in intermediate-risk breast cancer, informing European guideline recommendations for gene expression profiling.
Representative Works 代表性著作
Prospective Validation of the uPA/PAI-1 Test in Early Breast Cancer
Journal of the National Cancer Institute (2013)
Definitive prospective validation of uPA/PAI-1 protein biomarkers for chemotherapy decisions.
EndoPredict Predicts Clinical Outcome of ER+/HER2- Breast Cancer Patients
Annals of Oncology (2012)
Validation of EndoPredict gene expression signature for breast cancer risk stratification.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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University of California, San Francisco (UCSF)
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Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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