Miriam Merad
米里亚姆·梅拉德
MD, PhD
Director, Precision Immunology Institute; Professor of Oncological Sciences and Immunology精准免疫学研究所所长；肿瘤学与免疫学教授
👥Biography 个人简介
Miriam Merad at Icahn School of Medicine is a world leader in myeloid cell and dendritic cell biology. Her discoveries on tissue-resident macrophage ontogeny and the heterogeneity of tumor-infiltrating myeloid cells—enabled by single-cell technologies she helped pioneer—have reshaped understanding of tumor immune microenvironments and myeloid-targeted therapy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Tissue-Resident Macrophage Ontogeny
Demonstrated that many tissue-resident macrophages, including microglia and Kupffer cells, are embryonically seeded and self-renew independently of bone marrow precursors, redefining macrophage classification relevant to tumor-associated macrophage subsets.
Tumor Dendritic Cell Heterogeneity
Used single-cell transcriptomics to map the diversity of conventional and plasmacytoid dendritic cell subsets within human tumors, identifying DC subsets critical for cross-presentation and anti-tumor T cell priming.
Myeloid Cell Targeting in Cancer
Developed strategies to repolarize immunosuppressive tumor-associated macrophages and boost dendritic cell function in vivo, enabling synergy with checkpoint blockade and demonstrating durable anti-tumor responses.
Representative Works 代表性著作
The dendritic cell lineage: ontogeny and function of dendritic cells and their precursors in steady state and the inflamed setting
Annual Review of Immunology (2013)
Definitive review of DC ontogeny, subset specification, and function across tissues that remains a standard reference for myeloid cell biologists studying tumor immunity.
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
Immunity (2013)
Landmark study establishing the embryonic origin and local self-renewal of tissue macrophages using parabiosis models, overturning the classic monocyte-replacement paradigm.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
关注 米里亚姆·梅拉德 的研究动态
Follow Miriam Merad's research updates
留下邮箱，当我们发布与 Miriam Merad（Icahn School of Medicine at Mount Sinai）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment