Mimi I. Hu
胡咪咪
MD
Associate Professor, Department of Endocrine Neoplasia and Hormonal Disorders内分泌肿瘤与激素紊乱科副教授
👥Biography 个人简介
Dr. Mimi Hu is a leading expert in medullary thyroid cancer and RET-targeted therapy at MD Anderson. She has conducted pivotal clinical research on cabozantinib and vandetanib, and is at the forefront of evaluating next-generation selective RET inhibitors (selpercatinib, pralsetinib) for hereditary and sporadic MTC.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Medullary Thyroid Cancer Systemic Therapy
Led clinical trials and correlative studies establishing cabozantinib and vandetanib as standards of care for progressive metastatic medullary thyroid cancer, characterizing molecular predictors of response including RET mutation subtype.
Selective RET Inhibitor Trials
Contributed to the LIBRETTO-001 trial of selpercatinib and ARROW trial of pralsetinib, demonstrating superior response rates and tolerability of selective RET inhibitors over multi-kinase inhibitors in MTC.
Representative Works 代表性著作
Cabozantinib in progressive, metastatic medullary thyroid cancer (EXAM trial)
Journal of Clinical Oncology (2013)
Phase III EXAM trial demonstrating cabozantinib improved PFS in medullary thyroid cancer, leading to FDA approval as a standard treatment option.
Selpercatinib in RET-mutant medullary thyroid cancer: efficacy and safety from LIBRETTO-001
NEJM (2020)
Pivotal trial showing high and durable response rates with selpercatinib in RET-mutant MTC, supporting FDA approval of selective RET inhibition.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Hope S. Rugo
University of California, San Francisco (UCSF)
Maryam B. Lustberg
Yale School of Medicine / Yale Cancer Center
Sara M. Tolaney
Dana-Farber Cancer Institute / Harvard Medical School
Carlos H. Barrios
PUCRS (Pontifical Catholic University of Rio Grande do Sul) / Hospital São Lucas, Porto Alegre, Brazil
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