Meera Agar
米拉·阿加尔
MBBS, PhD, FRACP, FAChPM
Professor of Palliative Medicine; Director, Improving Palliative, Aged and Chronic Care through Clinical Research and Translation (IMPACCT)姑息医学教授;IMPACCT主任
👥Biography 个人简介
Meera Agar, MBBS, PhD, FRACP, FAChPM is Professor of Palliative Medicine at the University of Technology Sydney and Director of IMPACCT (Improving Palliative, Aged and Chronic Care through Clinical Research and Translation). A world leader in clinical research in palliative medicine, Professor Agar is best known for her landmark multisite randomized trial, published in JAMA Internal Medicine in 2017, which challenged the widespread use of haloperidol and risperidone for managing agitated delirium at the end of life, demonstrating that antipsychotics provided no benefit over placebo and were associated with increased distress. This practice-changing study reshaped international guidelines on delirium management in the dying patient. Professor Agar leads the Palliative Care Clinical Studies Collaborative (PaCCSC) in Australia, one of the few national networks conducting rigorous phase III clinical trials in palliative medicine. Her research spans delirium pathophysiology, hospice quality indicators, advance care planning implementation, and the ethics of end-of-life sedation. She has published over 230 peer-reviewed papers and is a recipient of the NHMRC Practitioner Fellowship.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Antipsychotics for Delirium at End of Life — Practice-Changing Trial
Led the landmark JAMA Internal Medicine multisite RCT demonstrating that haloperidol and risperidone were no better than placebo and caused greater distress for agitated delirium in dying cancer patients, fundamentally changing international guideline recommendations for terminal delirium management.
PaCCSC: National Clinical Trials Infrastructure in Palliative Medicine
Co-founded and leads the Palliative Care Clinical Studies Collaborative (PaCCSC), Australia's national network for conducting phase II/III RCTs in palliative care, enabling a portfolio of rigorously designed trials addressing key symptom management questions.
Advance Care Planning Dissemination and Implementation
Conducted pragmatic implementation trials of advance care planning in Australian health services, identifying enablers, barriers, and scalable models for embedding ACP conversations into routine care for patients with advanced illness.
Representative Works 代表性著作
Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care
JAMA Internal Medicine (2017)
Practice-changing multisite RCT demonstrating antipsychotics were no more effective than placebo and associated with greater distress for patients with agitated delirium at end of life, reshaping palliative care guidelines internationally.
Advance Care Planning in Australia: A Systematic Review
BMJ Open (2021)
National systematic review synthesizing evidence on advance care planning implementation barriers, enablers, and outcomes in Australian health services.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-20 | All information from publicly available academic sources
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