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Meera Agar

米拉·阿加尔

MBBS, PhD, FRACP, FAChPM

🏢University of Technology Sydney; IMPACCT Research Centre(悉尼科技大学;IMPACCT研究中心)🌐Australia

Professor of Palliative Medicine; Director, Improving Palliative, Aged and Chronic Care through Clinical Research and Translation (IMPACCT)姑息医学教授;IMPACCT主任

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Meera Agar, MBBS, PhD, FRACP, FAChPM is Professor of Palliative Medicine at the University of Technology Sydney and Director of IMPACCT (Improving Palliative, Aged and Chronic Care through Clinical Research and Translation). A world leader in clinical research in palliative medicine, Professor Agar is best known for her landmark multisite randomized trial, published in JAMA Internal Medicine in 2017, which challenged the widespread use of haloperidol and risperidone for managing agitated delirium at the end of life, demonstrating that antipsychotics provided no benefit over placebo and were associated with increased distress. This practice-changing study reshaped international guidelines on delirium management in the dying patient. Professor Agar leads the Palliative Care Clinical Studies Collaborative (PaCCSC) in Australia, one of the few national networks conducting rigorous phase III clinical trials in palliative medicine. Her research spans delirium pathophysiology, hospice quality indicators, advance care planning implementation, and the ethics of end-of-life sedation. She has published over 230 peer-reviewed papers and is a recipient of the NHMRC Practitioner Fellowship.

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🧪Research Fields 研究领域

Delirium in Palliative Care姑息治疗中的谵妄
End-of-Life Sedation临终镇静
Hospice Quality Improvement临终关怀质量改进
Palliative Care Clinical Trials姑息治疗临床试验
Advance Care Planning Implementation预先护理计划实施

🎓Key Contributions 主要贡献

Antipsychotics for Delirium at End of Life — Practice-Changing Trial

Led the landmark JAMA Internal Medicine multisite RCT demonstrating that haloperidol and risperidone were no better than placebo and caused greater distress for agitated delirium in dying cancer patients, fundamentally changing international guideline recommendations for terminal delirium management.

PaCCSC: National Clinical Trials Infrastructure in Palliative Medicine

Co-founded and leads the Palliative Care Clinical Studies Collaborative (PaCCSC), Australia's national network for conducting phase II/III RCTs in palliative care, enabling a portfolio of rigorously designed trials addressing key symptom management questions.

Advance Care Planning Dissemination and Implementation

Conducted pragmatic implementation trials of advance care planning in Australian health services, identifying enablers, barriers, and scalable models for embedding ACP conversations into routine care for patients with advanced illness.

Representative Works 代表性著作

[1]

Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care

JAMA Internal Medicine (2017)

Practice-changing multisite RCT demonstrating antipsychotics were no more effective than placebo and associated with greater distress for patients with agitated delirium at end of life, reshaping palliative care guidelines internationally.

[2]

Advance Care Planning in Australia: A Systematic Review

BMJ Open (2021)

National systematic review synthesizing evidence on advance care planning implementation barriers, enablers, and outcomes in Australian health services.

🏆Awards & Recognition 奖项与荣誉

🏆NHMRC Practitioner Fellowship
🏆Palliative Care Australia Research Excellence Award
🏆Cancer Institute NSW Career Development Fellowship

📄Data Sources 数据来源

Last updated: 2026-01-20 | All information from publicly available academic sources

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